|
Mental Depression
|
0.320 |
Biomarker
|
disease |
PSYGENET |
In mice over-expressing neuronal CRF (an animal model for depression) the expression of urocortin 1 (Ucn1) in the non-preganglionic Edinger-Westphal nucleus (npEW) is strongly down-regulated.
|
18329817 |
2008 |
|
Mental Depression
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
In mice over-expressing neuronal CRF (an animal model for depression) the expression of urocortin 1 (Ucn1) in the non-preganglionic Edinger-Westphal nucleus (npEW) is strongly down-regulated.
|
18329817 |
2008 |
|
Depressive disorder
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
In mice over-expressing neuronal CRF (an animal model for depression) the expression of urocortin 1 (Ucn1) in the non-preganglionic Edinger-Westphal nucleus (npEW) is strongly down-regulated.
|
18329817 |
2008 |
|
Depressive disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
In mice over-expressing neuronal CRF (an animal model for depression) the expression of urocortin 1 (Ucn1) in the non-preganglionic Edinger-Westphal nucleus (npEW) is strongly down-regulated.
|
18329817 |
2008 |
|
Mental Depression
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
These data indicate that CRF receptor antagonists may be useful for the treatment of the disease states where CRF is elevated such as anxiety and depression, anorexia nervosa and stroke and that ligand inhibitors of CRF-BP may be used to elevate brain levels of 'free' urocortin and other CRF-related peptides.
|
9118350 |
1996 |
|
Mental Depression
|
0.320 |
Biomarker
|
disease |
PSYGENET |
These data indicate that CRF receptor antagonists may be useful for the treatment of the disease states where CRF is elevated such as anxiety and depression, anorexia nervosa and stroke and that ligand inhibitors of CRF-BP may be used to elevate brain levels of 'free' urocortin and other CRF-related peptides.
|
9118350 |
1996 |
|
Depressive disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
These data indicate that CRF receptor antagonists may be useful for the treatment of the disease states where CRF is elevated such as anxiety and depression, anorexia nervosa and stroke and that ligand inhibitors of CRF-BP may be used to elevate brain levels of 'free' urocortin and other CRF-related peptides.
|
9118350 |
1996 |
|
Depressive disorder
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
These data indicate that CRF receptor antagonists may be useful for the treatment of the disease states where CRF is elevated such as anxiety and depression, anorexia nervosa and stroke and that ligand inhibitors of CRF-BP may be used to elevate brain levels of 'free' urocortin and other CRF-related peptides.
|
9118350 |
1996 |
|
Anxiety Disorders
|
0.310 |
Biomarker
|
group |
BEFREE |
Helicobacter pylori Vacuolating Cytotoxin A Causes Anorexia and Anxiety via Hypothalamic Urocortin 1 in Mice.
|
30979915 |
2019 |
|
Hypertensive disease
|
0.310 |
Therapeutic
|
group |
CTD_human |
Effect of long-term treatment with urocortin on the activity of somatic angiotensin-converting enzyme in spontaneously hypertensive rats.
|
20237592 |
2010 |
|
Anxiety Disorders
|
0.310 |
Biomarker
|
group |
CTD_human |
Previous studies have shown that injections of the anxiety-related neuropeptide corticotropin-releasing factor or the related neuropeptide urocortin 1 into the region of the basolateral amygdaloid nucleus induce anxiety-like behavior in several behavioral paradigms.
|
16488545 |
2006 |
|
Hypertensive disease
|
0.310 |
AlteredExpression
|
group |
BEFREE |
High maternal and fetal plasma urocortin levels in pregnancies complicated by hypertension.
|
16915033 |
2006 |
|
Inflammation
|
0.310 |
AlteredExpression
|
phenotype |
LHGDN |
Urocortin in human gastric mucosa: relationship to inflammatory activity.
|
12519893 |
2003 |
|
Inflammation
|
0.310 |
Therapeutic
|
phenotype |
CTD_human |
Therefore, we examined the parallel effects of urocortin- and hydralazine-induced hypotension on acute inflammation induced by carrageenin in the rat.
|
10213916 |
1999 |
|
Anxiety States, Neurotic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Injections of urocortin 1 into the basolateral amygdala induce anxiety-like behavior and c-Fos expression in brainstem serotonergic neurons.
|
16488545 |
2006 |
|
Anxiety neurosis (finding)
|
0.300 |
Biomarker
|
disease |
CTD_human |
Injections of urocortin 1 into the basolateral amygdala induce anxiety-like behavior and c-Fos expression in brainstem serotonergic neurons.
|
16488545 |
2006 |
|
Hypotension
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Therefore, we examined the parallel effects of urocortin- and hydralazine-induced hypotension on acute inflammation induced by carrageenin in the rat.
|
10213916 |
1999 |
|
Asthma
|
0.210 |
AlteredExpression
|
disease |
BEFREE |
Polydatin protects against ovalbumin-induced bronchial asthma in rats; involvement of urocortin and surfactant-D expression.
|
30422021 |
2019 |
|
Asthma
|
0.210 |
Biomarker
|
disease |
RGD |
Rats in asthma model group developed severe infiltration of inflammatory cells and inflammation in airway, together with a significantly up-regulated expression of urocortin mRNA detected by semi-quantitative reverse transcriptase-polymerase chain reaction and peptide measured both by immunohistochemistry and Western blot analysis.
|
16427607 |
2006 |
|
Colitis
|
0.200 |
Biomarker
|
disease |
RGD |
Urocortin 1 modulates immunosignaling in a rat model of colitis via corticotropin-releasing factor receptor 2.
|
21330446 |
2011 |
|
Parkinsonian Disorders
|
0.200 |
Biomarker
|
group |
RGD |
Odorranalectin-conjugated nanoparticles: preparation, brain delivery and pharmacodynamic study on Parkinson's disease following intranasal administration.
|
21362449 |
2011 |
|
Thromboangiitis Obliterans
|
0.200 |
Biomarker
|
disease |
RGD |
Here we have examined the effects of urocortin on sodium laurate-induced peripheral arterial vasculitis in rats, modelling the mechanisms of thromboangiitis obliterans (TAO).
|
19572944 |
2009 |
|
Myocardial Reperfusion Injury
|
0.200 |
Biomarker
|
phenotype |
RGD |
Mechanisms of the protective effects of urocortin on coronary endothelial function during ischemia-reperfusion in rat isolated hearts.
|
15806110 |
2005 |
|
Left Ventricular Hypertrophy
|
0.200 |
Biomarker
|
disease |
RGD |
Urocortin mRNA expression is higher in left ventricular (LV) hypertrophy than in normal LV, whereas CRF-R2beta mRNA expression is markedly depressed in LV hypertrophy compared with normal LV.
|
11087261 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The in vivo studies also supported the findings and showed better comprehensive residence time (23.61 ± 1.75 h), tumor distribution profile than UCN 01 alone.
|
30942626 |
2019 |