UCP1, uncoupling protein 1, 7350

N. diseases: 124; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011991
Disease: Diarrhea
Diarrhea 		0.010 Biomarker phenotype BEFREE A trend toward a longer duration of diarrhea was seen for the TAMU (94.5 h) versus UCP (81.6 h) and Iowa (64.2 h) isolates. 10479158 1999
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE Some of these genes may promote obesity by gene-gene interactions (for example beta 3-adrenoceptors and uncoupling protein-1) or gene-environment interactions (for example beta 2-adrenoceptors and physical activity). 10889786 2000
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE The human uncoupling protein-1 gene (UCP1): present status and perspectives in obesity research. 12119988 2000
CUI: C0028754
Disease: Obesity
Obesity 		0.400 GeneticVariation disease BEFREE In conclusion, the present study failed to demonstrate an additive or synergistic effect of the Trp/Arg64 variant of the BAR gene and the -3826 A-->G variant of the UCP1 gene on the development of obesity and insulin resistance among randomly recruited Danish Caucasian subjects. 10999801 2000
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE In overweight Australian women the -3826 G variant of UCP-1 increased the susceptibility to obesity indicating that UCP-1 could be involved in weight regulation. 10753048 2000
CUI: C0023804
Disease: Lipomatosis, Multiple Symmetrical
Lipomatosis, Multiple Symmetrical 		0.030 AlteredExpression disease BEFREE We determined that brown adipose tissue-specific uncoupling protein-1 (UCP-1) mRNA is expressed in the lipoma of a multiple symmetric lipomatosis patient bearing the 8344 mutation in the tRNALys gene of mitochondrial DNA. 11095987 2000
CUI: C0023798
Disease: Lipoma
Lipoma 		0.010 AlteredExpression disease BEFREE UCP1 mRNA was not detected in normal subcutaneous fat from the same patient or in the lipoma of another patient bearing a different mutation in the same tRNALys gene. 11095987 2000
CUI: C3489413
Disease: Lipomatosis, Multiple
Lipomatosis, Multiple 		0.010 AlteredExpression disease BEFREE UCP1 mRNA was not detected in normal subcutaneous fat from the same patient or in the lipoma of another patient bearing a different mutation in the same tRNALys gene. 11095987 2000
CUI: C0028754
Disease: Obesity
Obesity 		0.400 AlteredExpression disease BEFREE UCP1 expression is positively correlated with metabolic inefficiency, being increased by cold acclimation (in adults or perinatally) and overfeeding, and reduced in fasting and genetic obesity. 11239487 2001
CUI: C0028754
Disease: Obesity
Obesity 		0.400 GeneticVariation disease BEFREE We suggest a role for UCP-1 polymorphism in the pathogenesis of obesity and arteriosclerosis. 11341297 2001
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE Like its close relatives UCP1 and UCP3, UCP2 uncouples proton entry in the mitochondrial matrix from ATP synthesis and is therefore a candidate gene for obesity. 11381268 2001
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE The contribution of UCP genes towards polygenic obesity and Type II diabetes is evaluated and discussed. 11484071 2001
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 GeneticVariation disease BEFREE Both the A-->C polymorphism and the Met229-->Leu polymorphism of UCP1 are in linkage disequilibrium and could be one of the diabetes associated single nucleotide polymorphisms (SNPs). 11317671 2001
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.100 GeneticVariation group BEFREE Both the A-->C polymorphism and the Met229-->Leu polymorphism of UCP1 are in linkage disequilibrium and could be one of the diabetes associated single nucleotide polymorphisms (SNPs). 11317671 2001
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.100 GeneticVariation disease BEFREE We screened the human UCP1 gene (UCP1) for polymorphisms associated with susceptibility to Type II diabetes. 11317671 2001
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.100 GeneticVariation disease BEFREE GG-genotype in the promotor region of uncoupling-protein-1 gene is associated with lower level of dehydroepiandrosterone in type 2 diabetes. 11341297 2001
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.100 Biomarker disease BEFREE The contribution of UCP genes towards polygenic obesity and Type II diabetes is evaluated and discussed. 11484071 2001
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.050 GeneticVariation disease BEFREE We suggest a role for UCP-1 polymorphism in the pathogenesis of obesity and arteriosclerosis. 11341297 2001
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE Expression of UCP1 from the adipose-specific promoter in the aP2-Ucp1 transgenic mice mitigated obesity induced by genetic or dietary factors. 12079839 2002
CUI: C0028754
Disease: Obesity
Obesity 		0.400 AlteredExpression disease BEFREE A common Bcl I polymorphism in the promoter region of the UCP-1 gene is associated with reduced UCP-1 adipose tissue mRNA and obesity. 12029453 2002
CUI: C0028754
Disease: Obesity
Obesity 		0.400 GeneticVariation disease BEFREE Correlation of the -3826A >G polymorphism in the promoter of the uncoupling protein 1 gene with obesity and metabolic disorders in obese families from southern Poland. 12375583 2002
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.100 GeneticVariation group BEFREE Correlation of the -3826A >G polymorphism in the promoter of the uncoupling protein 1 gene with obesity and metabolic disorders in obese families from southern Poland. 12375583 2002
CUI: C0023804
Disease: Lipomatosis, Multiple Symmetrical
Lipomatosis, Multiple Symmetrical 		0.030 Biomarker disease BEFREE Cultured MSL adipocytes were able to synthesize UCP-1 (the selective marker of brown adipocytes), but unlike that of normally functioning brown fat cells, the expression of the UCP-1 gene was not significantly induced by NA. 12375271 2002
CUI: C0038644
Disease: Sudden infant death syndrome
Sudden infant death syndrome 		0.010 GeneticVariation disease BEFREE Our data do not support a major association between the occurrence of sudden infant death and two common functional polymorphisms in the human uncoupling protein-1 and beta3-adrenergic receptor genes. 12029453 2002
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE We examined the expression of PGC-1, PPAR gamma, insulin receptor substrate-1 (IRS-1), glucose transporter isoform-4 (GLUT-4), and mitochondrial uncoupling protein-1 (UCP-1) in adipose tissue and skeletal muscle from non-obese, non-diabetic insulin-resistant, and insulin-sensitive individuals. 12565902 2003