UCP2, uncoupling protein 2, 7351

N. diseases: 235; N. variants: 5
Disease: Hyperglycemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.050 AlteredExpression disease BEFREE In contrast, UCP2 overexpression improves both hyperglycemia- and high-salt diet-induced endothelial dysfunction and ameliorates hypertensive target organ damage in SHRSP. 29163755 2017
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.050 Biomarker disease BEFREE Our results indicate that endothelial UCP2 may function as a sensor and negative regulator of mitochondrial ROS production in response to hyperglycemia. 25910810 2015
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.050 GeneticVariation disease BEFREE A common, functional polymorphism in the promoter region of the UCP2 gene is associated with hyperglycaemia and insulin resistance in severe sepsis. 19556617 2009
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.050 AlteredExpression disease LHGDN Increased expression of UCP-2 and decreased expression of UCP-3 in humans with chronic hyperglycemia may contribute to impaired glucose-stimulated insulin secretion. 18167556 2008
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.050 Biomarker disease BEFREE In ob/ob mice, induction of UCP2 at age 5 weeks precedes development of insulin secretion defects and hyperglycaemia. 17052202 2006