|
Urinary tract infection
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Indeed, mutations in THP cause a group of inherited kidney diseases, and altered THP expression is associated with increased risks of urinary tract infection, kidney stone, hypertension, hyperuricemia and acute and chronic kidney diseases.
|
30649494 |
2020 |
|
Urinary tract infection
|
0.100 |
Biomarker
|
group |
BEFREE |
UMOD has multiple functions such as protection against urinary tract infections and nephrolithiasis.
|
31205055 |
2019 |
|
Urinary tract infection
|
0.100 |
Biomarker
|
group |
BEFREE |
Urinary tract infections and pyelonephritides may represent a clinical feature of uromodulin malfunction as it plays a protective role against urinary tract infections despite only sporadic data on this topic.
|
30976393 |
2019 |
|
Urinary tract infection
|
0.100 |
Biomarker
|
group |
BEFREE |
The concentrations of uUMOD in groups 1 and 2 tended to decrease with the time from inoculation, whereas it rapidly increased in group 3 at 21 days postinfection. uKIM-1 seems to be the only marker of ascending AKI associated with urinary tract infection.
|
30552306 |
2018 |
|
Urinary tract infection
|
0.100 |
Biomarker
|
group |
BEFREE |
The function of uromodulin remains elusive, but the available data suggest that this protein might regulate salt transport, protect against urinary tract infection and kidney stones, and have roles in kidney injury and innate immunity.
|
28781372 |
2017 |
|
Urinary tract infection
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Higher levels of uromodulin are associated with lower risk of urinary tract infections in older adults.
|
27898524 |
2017 |
|
Urinary tract infection
|
0.100 |
Biomarker
|
group |
BEFREE |
This finding supports prior laboratory data indicating a protective role of uromodulin against UTI.
|
28029393 |
2017 |
|
Urinary tract infection
|
0.100 |
Biomarker
|
group |
BEFREE |
Despite an amplified biological effect of the homozygote mutation, the proband did not show a strikingly more severe clinical evolution nor was the near absence of urinary uromodulin associated with urinary tract infections or kidney stones.
|
28605509 |
2017 |
|
Urinary tract infection
|
0.100 |
Biomarker
|
group |
BEFREE |
These data strongly suggest that the UMOD ancestral allele, driving higher urinary excretion of uromodulin, has been kept at a high frequency because of its protective effect against UTIs.
|
26966016 |
2016 |
|
Urinary tract infection
|
0.100 |
Biomarker
|
group |
BEFREE |
UMOD has been linked to water/electrolyte balance and to kidney innate immunity and it is believed to protect against urinary tract infections and renal stones.
|
25228753 |
2015 |
|
Urinary tract infection
|
0.100 |
Biomarker
|
group |
BEFREE |
Uromodulin is believed to protect against urinary tract infections and stones, but its other physiologic functions have remained obscure until recently.
|
23880785 |
2014 |
|
Urinary tract infection
|
0.100 |
Biomarker
|
group |
BEFREE |
Uromodulin (also known as Tamm-Horsfall protein) is the most abundant urinary protein in healthy individuals and exhibits diverse functions including prevention of ascending urinary tract infections by binding type I-fimbriated Escherichia coli.
|
20075439 |
2010 |
|
Urinary tract infection
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, genetic ablation of the THP gene was shown to lead to severe infection and lethal pyelonephritis in experimental models of UTI.
|
15989109 |
2005 |