Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
The present study further investigated whether inhibition of angiotensin-converting enzyme (ACE) or tumor necrosis factor-α (TNF-α) blocks sensitization of ANG II hypertension in offspring of HFD dams.
|
31746626 |
2020 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Ang II (angiotensin II) increased Ca<sup>2+</sup> and Na<sup>+</sup> influx with exaggerated responses in hypertension.
|
31735084 |
2020 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
In POP<sup>-/-</sup> mice, the increase in Ang-(1-7) was also blunted as compared with WT mice (309±46 and 472±28 fmol/mL, respectively <i>P</i>=0.01), and moreover, the rate of recovery from acute Ang II-induced hypertension was delayed (<i>P</i>=0.016).
|
31786979 |
2020 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Targeting Ang III by inhibiting brain APA is now considered a potentially important target in the management of hypertension.
|
31786978 |
2020 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
The molecular mechanism of albuminuria upon Ang II-induced hypertension is not fully understood.
|
31241148 |
2020 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Losartan, an angiotensin II (Ang II) receptor blocker acting on the Ang II type-1 receptor (AT1R) subtype, is a prescription drug for treating hypertension.
|
30991833 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Further, cyclooxygenase (Cox)-derived prostanoids were implicated in Ang II-dependent hypertension.
|
31378306 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Chronical infusion of Ang II via implanted osmotic mini-pump induced increased blood pressure and cardiac hypertrophy in vivo.
|
31015570 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Deletion of <i>Rcn2</i> lowered basal blood pressure and attenuated ANG II-induced hypertension in C57BL/6 mice. siRNA knockdown of <i>Rcn2</i> dramatically increased production of the nitric oxide (NO) breakdown products nitrite and nitrate by endothelial cells but not by smooth muscle cells.
|
30943068 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we hypothesized that treatment with inorganic nitrate could prevent the increase in sympathetic nerve activity in an experimental model of Ang II (angiotensin II)-induced hypertension.
|
30712424 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
The present study aimed to determine the role of endothelial mTORC1 in Ang II (angiotensin II)-induced hypertension and the underlying mechanism.
|
31378107 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Ang II (angiotensin II) was infused subcutaneously using osmotic mini-pumps to induce hypertension.
|
30612527 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo miR-431-5p knockdown delayed Ang II-induced blood pressure elevation and reduced vascular injury in mice, which demonstrated its potential as a target for treatment of hypertension and vascular injury.
|
30929512 |
2019 |
Hypertensive disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These findings suggest that Sulf2 is an up-regulatory factor in the additive action of CXCL8 via the AT<sub>1</sub> R pathway on Ang II-induced ET-1 expression in VSMCs under hypertension environment.
|
30470661 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we deleted TASK-1 and TASK-3 channels selectively from zona glomerulosa cells and generated a model of mild aldosterone autonomy with attendant hypertension that is aldosterone-driven and Ang II (angiotensin II)-independent.
|
30580687 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Atrial fibrillation (AF) commonly occurs in hypertension and in association with elevated Ang II (angiotensin II) levels.
|
30636477 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
The emerging view of alternative pathways within the RAS that may functionally antagonize the Ang II axis raise the possibility that programming events also target the non-classical components of the RAS as an additional mechanism contributing to the development and progression of hypertension.
|
30622158 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
MicroRNA-31 Regulates Immunosuppression in Ang II (Angiotensin II)-induced Hypertension by Targeting Ppp6C (Protein Phosphatase 6c).
|
30929511 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Blockade of DP1R with BWA868C, however, increased the magnitude of Ang II-salt hypertension and significantly increased neurogenic pressor activity.
|
31587572 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Background Angiotensin II (Ang II) can cause hypertension and tissue impairment via AGTR1 (Ang II receptor type 1), particularly in renal proximal tubule cells, and can cause DNA damage in renal cells via nicotinamide adenine dinucleotide phosphate oxidase.
|
31787052 |
2019 |
Hypertensive disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, NHE3 in the proximal tubules of the kidney may be a therapeutical target in hypertension induced by Ang II or with increased NHE3 expression in the proximal tubules.
|
31352824 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Ang II-induced increase in hypertension, cardiac performance, hypertrophy and fibrosis, inflammatory response, and activation of the NF-kB and TGF-β1/Smad2/3 pathways was significantly aggravated in CD1d knockout (CD1dko) mice compared with wild-type (WT) mice, but these effects were markedly abrogated in WT mice treated with α-galactosylceramide (αGC), a specific activator of NKT cells.
|
29939225 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Involvement of the MiR-181b-5p/HMGB1 Pathway in Ang II-induced Phenotypic Transformation of Smooth Muscle Cells in Hypertension.
|
31011475 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together with our previous work, this study provides insight into how acute estrogen signaling via GPER provides cardiovascular protection during Ang II hypertension and potentially other diseases characterized by increased oxidative stress.
|
31507536 |
2019 |
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Scavenging cellular reactive oxygen species (ROS) with tempol in brain fails to correct either hypertension or sympathovagal balance in these animals, despite reports that mitochondrial ROS contributes to Ang II-infusion hypertension.
|
30540685 |
2019 |