|
Aortic Aneurysm, Abdominal
|
0.100 |
Biomarker
|
disease |
BEFREE |
SM22α knockdown in ApoE<sup>-/-</sup> (apolipoprotein E-deficient) mice treated with Ang II (angiotensin II) accelerated the formation of AAAs, as evidenced by a larger maximal aortic diameter and more medial elastin degradation than those found in control mice, whereas SM22α overexpression exerted opposite effects.
|
30580562 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of SCO2 restored the beneficial effect of CR on antagonizing Ang II-induced expression of AAA-related molecules and reactive oxygen species generation in p53<sup>-/-</sup> vascular smooth muscle cells.
|
30686087 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Angiotensin II (Ang-II) was used to construct the AAA model in <i>ApoE</i><sup>-<i>/</i>-</sup> mice.
|
31467666 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, Ang II infusion markedly increased the incidence and severity of AAA in ApoE KO mice, which was considerably reduced in LMP7/ApoE dKO mice.
|
30642978 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Deficiency of IL12p40 (Interleukin 12 p40) Promotes Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysm.
|
30580570 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Osmotic minipumps with a continuous infusion of Ang II (angiotensin II; 1000 ng/[kg·min]) to induce AAAs were implanted in apolipoprotein-deficient mice (N=58).Animals were assigned to 2 groups.
|
30871334 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
Biomarker
|
disease |
BEFREE |
ApoEKO mice were fed a high-fat diet (HFD) and infused with angiotensin (Ang) II by osmotic mini pumps for 4 weeks to induce AAA with (DPP-4i group) or without (control group) teneligliptin administered orally from 1 week before HFD and Ang II infusion to the end of the experiment.
|
29321388 |
2018 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we demonstrated that intraperitoneal injection of leptin attenuated Ang II-induced AAA formation in ApoE-/- mice with no effect on serum lipids and systolic blood pressure.
|
30054042 |
2018 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Approach and Results- Using a single intravenous injection protocol, we transfected an IL-10 transcribing nonimmunogenic minicircle vector into the Ang II (angiotensin II)-ApoE<sup>-/-</sup> infusion mouse model of AAA.
|
29880489 |
2018 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Angiotensin (Ang) II type 1 receptor (AT1) activation is essential for the development of exogenous Ang II-induced abdominal aortic aneurysms (AAAs) in hyperlipidemic animals.
|
28434702 |
2018 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ang II infusion increased PARP-1 expression and activity and successfully induced AAA formation partly with a hemorrhage in ApoE<sup>-/-</sup> mice.
|
30354818 |
2018 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice with SMC ATG7 deficiency that are chronically infused with Ang II do not tend to develop dissecting AAA but do exhibit adverse aortic remodeling and appreciable cardiac failure-associated mortality.
|
29273297 |
2018 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Because RAS activation and Ang-II signalling are implicated in metabolic syndrome (MS) and abdominal aortic aneurysm (AAA), we investigated the effect of Ang-II on CXCL16 arterial expression, the underlying mechanisms, and the functional role of the CXCL16/CXCR6 axis in these cardiometabolic disorders.
|
29800106 |
2018 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
Biomarker
|
disease |
BEFREE |
TUDCA attenuates Ang II induced AAA formation in ApoE<sup>-/-</sup> mice by inhibiting ER stress mediated apoptosis.
|
27889204 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
Biomarker
|
disease |
BEFREE |
HIF-1KO and control mice were fed high-fat diet (HFD) and infused with angiotensin II (Ang II, 1800 ng/kg/min) by an osmotic mini pump for 4 weeks to induce AAA formation.
|
28196857 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggest that CAR-DCN treatment attenuates the formation and rupture of Ang II-induced AAA in mice by reinforcing the aortic wall.
|
29158532 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, MPO gene deletion and taurine administration significantly attenuated the induction of serum amyloid A, which promotes ANG II-induced AAAs.
|
28971841 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
Biomarker
|
disease |
BEFREE |
These effects seemed attributed to an endothelial specific restoration of dihydrofolate reductase expression and activity, deficiency of which has been shown to induce eNOS uncoupling and AAA formation in both Ang II-infused hph-1 and apoE null animals.
|
27912196 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the changes of spleen volume on AAA formation, apolipoprotein E knockout (Apo E<sup>-/-</sup>) mice were treated with Ang II (1000 ng/kg/min) up to 28 days to generate AAA.
|
29246140 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
Biomarker
|
disease |
BEFREE |
VDR activation reduces dissecting AAA formation induced by Ang-II in apoE(-/-) mice and may constitute a novel therapeutic strategy to prevent AAA progression.
|
27283745 |
2016 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast to experience with ascending aortic aneurysm in MFS, Wang and colleagues show that systemic abrogation of TGF-beta signaling worsens (rather than attenuates) Ang II-induced abdominal aortic aneurysm progression in mice.
|
20101091 |
2010 |
|
Aortic Aneurysm, Abdominal
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate that the pathological features of the aneurysmal remodelling induced by Ang II in old ApoE(0) mice are distinct from those of human AAA.
|
17828285 |
2007 |