UPK3A, uroplakin 3A, 7380

N. diseases: 25; N. variants: 2
Disease: Malignant neoplasm of urinary bladder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.020 AlteredExpression disease BEFREE Organoids from individual BC dogs were successfully generated, expressed urothelial cell markers (CK7, CK20, and UPK3A) and exhibited tumorigenesis in vivo. 31254429 2019
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.020 Biomarker disease BEFREE We describe here the first subtype-specific murine models of bladder cancer and show that Upk3a-Cre<sup>ERT2</sup>; Trp53<sup>L/L</sup>; Pten<sup>L/L</sup>; Rosa26<sup>LSL-Luc</sup> (UPPL, luminal-like) and BBN (basal-like) tumors are more faithful to human bladder cancer than the widely used MB49 cells. 29784854 2018