|
RENAL ADYSPLASIA
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
De novo UPIIIA mutations recently were identified in 4 of 17 patients with severe bilateral renal adysplasia.
|
16731295 |
2006 |
|
RENAL ADYSPLASIA
|
0.310 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Unilateral agenesis of kidney
|
0.300 |
GermlineCausalMutation
|
disease |
ORPHANET |
De novo Uroplakin IIIa heterozygous mutations cause human renal adysplasia leading to severe kidney failure.
|
15888565 |
2005 |
|
Vesico-Ureteral Reflux
|
0.250 |
AlteredExpression
|
disease |
LHGDN |
Up-regulation of urinary UPIII mRNA levels in vesicoureteral reflux patients: potential application as a screening test for vesicoureteral reflux.
|
17880289 |
2007 |
|
Vesico-Ureteral Reflux
|
0.250 |
AlteredExpression
|
disease |
BEFREE |
Up-regulation of urinary UPIII mRNA levels in vesicoureteral reflux patients: potential application as a screening test for vesicoureteral reflux.
|
17880289 |
2007 |
|
Vesico-Ureteral Reflux
|
0.250 |
Biomarker
|
disease |
BEFREE |
Uroplakin IIIa (encoded by UPIIIA) is an integral membrane protein present in urothelial plaques, and the murine UPIIIa knockout is associated with urothelial anomalies and vesicoureteral reflux.
|
16731295 |
2006 |
|
Vesico-Ureteral Reflux
|
0.250 |
Biomarker
|
disease |
BEFREE |
Uroplakin III is not a major candidate gene for primary vesicoureteral reflux.
|
15523493 |
2005 |
|
Vesico-Ureteral Reflux
|
0.250 |
GeneticVariation
|
disease |
BEFREE |
No pathogenic mutations in the uroplakin III gene of 25 patients with primary vesicoureteral reflux.
|
14713856 |
2004 |
|
Vesico-Ureteral Reflux
|
0.250 |
Biomarker
|
disease |
BEFREE |
Targeted disruption of angiotensin type II receptor and uroplakin III genes result in the phenotype of primary vesicoureteral reflux.
|
12640275 |
2003 |
|
Vesico-Ureteral Reflux
|
0.250 |
Biomarker
|
disease |
MGD |
Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux.
|
11085999 |
2000 |
|
Vesicoureteral Reflux 1
|
0.050 |
Biomarker
|
disease |
BEFREE |
Common genetic variants in four genes (GREM1, EYA1, ROBO2 and UPK3A) show a trend towards association with the development of primary VUR (GREM1, EYA1, ROBO2) or duplex collecting system (EYA1 and UPK3A).
|
22558067 |
2012 |
|
Vesicoureteral Reflux 1
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
UPIII mRNA was found to be up-regulated to a greater extent in VUR than in control exfoliated urinary cells (mean +/- SE: 497.0 +/- 178.5 copies vs. 69.0 +/- 10.0 copies, respectively, P < 0.001).
|
17880289 |
2007 |
|
Vesicoureteral Reflux 1
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
We were unable to detect linkage to any of the genes and loci and could exclude the GDNF, RET, SLIT2, SPRY1, PAX2, AGTR2, UPK1A and UPK3A genes and the 1p13 and 20p13 loci from linkage to VUR.
|
17497182 |
2007 |
|
Vesicoureteral Reflux 1
|
0.050 |
Biomarker
|
disease |
BEFREE |
Our results do not support a role for UPK3 in primary VUR.
|
15523493 |
2005 |
|
Vesicoureteral Reflux 1
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Although mutations in regulatory elements affecting gene function cannot be excluded, the UPIII gene does not seem to have a major role in primary VUR in humans.
|
14713856 |
2004 |
|
Bladder Neoplasm
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Organoids from individual BC dogs were successfully generated, expressed urothelial cell markers (CK7, CK20, and UPK3A) and exhibited tumorigenesis in vivo.
|
31254429 |
2019 |
|
Bladder Neoplasm
|
0.040 |
Biomarker
|
disease |
BEFREE |
We describe here the first subtype-specific murine models of bladder cancer and show that Upk3a-Cre<sup>ERT2</sup>; Trp53<sup>L/L</sup>; Pten<sup>L/L</sup>; Rosa26<sup>LSL-Luc</sup> (UPPL, luminal-like) and BBN (basal-like) tumors are more faithful to human bladder cancer than the widely used MB49 cells.
|
29784854 |
2018 |
|
Carcinoma, Transitional Cell
|
0.040 |
Biomarker
|
disease |
BEFREE |
To determine TERT promoter mutation status as well as the expression of PAX8, GATA3, p63, p40, p53 and uroplakin III in 17 patients with the upper urinary tract sarcomatoid urothelial carcinoma.
|
28052688 |
2017 |
|
Bladder Neoplasm
|
0.040 |
AlteredExpression
|
disease |
LHGDN |
Loss expression of uroplakin III is associated with clinicopathologic features of aggressive bladder cancer.
|
18313120 |
2008 |
|
Bladder Neoplasm
|
0.040 |
AlteredExpression
|
disease |
LHGDN |
Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder.
|
14654529 |
2003 |
|
Carcinoma, Transitional Cell
|
0.040 |
Biomarker
|
disease |
BEFREE |
This study investigated the expression of the four uroplakin genes, UPIa, UPIb, UPII and UPIII, in a wide range of normal human tissues to determine tissue specificity and in advanced transitional cell carcinoma (TCC) to examine gene expression in primary and metastatic disease.
|
12474225 |
2003 |
|
Carcinoma, Transitional Cell
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder.
|
14654529 |
2003 |
|
Carcinoma, Transitional Cell
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma.
|
9818021 |
1998 |
|
Interstitial Cystitis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Treatment with low-energy shock wave alleviates pain in an animal model of uroplakin 3A-induced autoimmune interstitial cystitis/painful bladder syndrome.
|
31501798 |
2019 |
|
Chronic interstitial cystitis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Treatment with low-energy shock wave alleviates pain in an animal model of uroplakin 3A-induced autoimmune interstitial cystitis/painful bladder syndrome.
|
31501798 |
2019 |