|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TP63 is a member of the TP53 gene family, sharing a common gene structure that produces two groups of mRNAs' encoding proteins with different N-terminal regions (ΔN and TA isoforms); both transcripts are also subjected to alternative splicing mechanisms at C-terminus, generating a variety of isoforms. p63 is a master regulator of epidermal development and homoeostasis as well as an important player in tumorigenesis and cancer progression with both oncogenic and tumour suppressive roles.
|
31789342 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry analysis of the tumor tissue showed CK5/6 (+), p63 (+), CD56 (+), and Ki-67 (+, approximately 30%), and genetic testing detected no <i>EGFR</i> mutation.
|
31417937 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, high p63 expression revealed a significant correlation with age (p=0.035), tumor type (p=0.004), American Joint Committee on Cancer stage (p=0.046), lymph node metastasis (p=0.006), lymphovascular invasion (p=0.006), distant metastasis (p=0.049), high Ki67 expression (p=0.000) and K-ras expression (p=0.002).
|
31056618 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
UVRAG is a tumor suppressor candidate involved in autophagy, which is truncated in cancers by a frameshift (FS) mutation and expressed as a shortened UVRAG<sup>FS</sup>.
|
31831743 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor was negative for pituitary markers and weakly positive for p63.
|
31491579 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Focal areas of the tumor demonstrated peripheral staining for p63 and CK5/6 suggestive of an in situ component.
|
29028127 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we show that the autophagic tumor suppressor UVRAG plays an integral role in melanogenesis by interaction with the biogenesis of lysosome-related organelles complex 1 (BLOC-1).
|
30061422 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemical staining for cytokeratin cocktail and p63 has been utilized to differentiate between these tumor types.
|
28968268 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
High expression of claudin-7 and low expression of c-kit and protein p63 are associated with higher tumour grade.
|
29475913 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor protein 53 (TP53) and its related family of p63 and p73 are tumor suppressor genes that regulate cellular activity to enhance longevity. p53 binds to specific response elements in DNA, modulating the transcription of genes that govern the major defenses against tumor growth.
|
29307398 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Bladder cancer (BC) ranks as the sixth most common cancer in the United States and is the leading cause of death in patients with urinary malignancies. p63 is a member of the p53 family and is believed to function as a tumor suppressor in human BCs.
|
30104251 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemical analysis for expression of cytokeratin (CK) AE1/AE3, CK7, CK5 + 8, CK14, vimentin, p63 and 14-3-3σ highlighted the biphasic nature of the neoplasm.
|
28942309 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, experimental evidence suggests that Beclin-1 inhibits tumor formation, angiogenesis, and metastasis alone and in cooperation with the tumor suppressive molecules UVRAG, Bif-1, Ambra1, and MDA-7/IL-24 via diverse mechanisms of action.
|
29405978 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
According to data from molecular cell biology, genetic models and clinic research, we conclude that p63 may act as either an oncogene or a tumor suppressor gene in different scenarios: TA isoforms of p63 gene are generally tumor-suppressive through repressing cell proliferation, survival and metastasis; ΔN isoforms, however, may initiate tumorigenesis via promoting cell proliferation and survival, but inhibit tumor metastasis and progression; effects of p63 on tumor formation and progression depend on the context of the whole p53 family, and either amplification or loss of p63 gene locus can break the balance to cause tumorigenesis.
|
28975366 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The tumor failed to express p63 and cytokeratin 5/6, whereas it was intensively positive for CK7 and E-cadherin.CDX2 expression was weak and focal.
|
29672360 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The pathway includes the tumor supressor protein p53, its vertebrate paralogs p63 and p73, and their negative regulators MDM2 and MDM4.
|
28774266 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The cells grew as a cohesive sheet of suspected carcinoma origin, and western blots showed positivity for the tumour marker p63 confirming cancerous origin.
|
28846747 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The study evaluated the expression of p63 and p73 isoforms and cell death receptors, and their relation to tumour recurrence and survival.
|
28350813 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, both NR4A2 and Notch1 suppressed the expression of tumor suppressors p21 and p63.
|
28423575 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The family of the p53 tumor suppressive transcription factors includes p73 and p63 in addition to p53 itself.
|
27091942 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data showed that p63 was a tumor suppressor mainly through regulating PTEN in chondrosarcoma cells.
|
29441939 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Statistically significant difference was observed between CD44 and p63 expression with tumor grade and stage with higher expression in high grade and advanced OSCCs.
|
28645102 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It is unclear if failure to stain with CK5/6 and p63 would be helpful in differentiating WDNETs from cutaneous adnexal neoplasms.
|
28417484 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Investigation of IGF2, IGFBP2 and p63 proteins in rhabdomyosarcoma tumors.
|
28129571 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This makes the identification of invasive regulator(s)/effector(s) as the potential therapeutic targets for managing BC a high priority. p63 is a member of the p53 family of tumor suppressor genes/proteins, plays a role in the differentiation of epithelial tissues, and is believed to function as a tumor suppressor.
|
28794159 |
2017 |