|
Psoriasis
|
0.600 |
Biomarker
|
disease |
MGD |
|
|
|
|
Psoriasis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Together, these findings suggest that TGF-alpha regulates VPF expression in psoriasis by an autocrine mechanism, leading to vascular hyperpermeability and angiogenesis.
|
8064230 |
1994 |
|
Psoriasis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In addition, VPF/VEGF is strongly expressed by epidermal keratinocytes in wound healing and psoriasis, disorders that are also characterized by increased microvascular permeability and angiogenesis.
|
7738351 |
1995 |
|
Psoriasis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Although increased expression of vascular endothelial growth factor protein was detected in the epidermis, the intensity of this staining was weak compared with the epidermal staining in psoriatic lesions and compared with the strong vascular endothelial growth factor mRNA signal in chronic wounds and psoriasis.
|
10886501 |
2000 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results suggest that alterations in the biology of VEGF may be involved in the pathogenesis of psoriasis.
|
14962110 |
2004 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
CTD_human |
In future, determination of VEGF gene polymorphisms and thus individual patient VEGF "signatures" may be used as a prognostic factor for psoriasis susceptibility/severity and as a means for optimizing treatment response.
|
16385345 |
2006 |
|
Psoriasis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Vascular endothelial growth factor gene polymorphisms increase the risk to develop psoriasis.
|
16630077 |
2006 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
LHGDN |
In future, determination of VEGF gene polymorphisms and thus individual patient VEGF "signatures" may be used as a prognostic factor for psoriasis susceptibility/severity and as a means for optimizing treatment response.
|
16385345 |
2006 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In future, determination of VEGF gene polymorphisms and thus individual patient VEGF "signatures" may be used as a prognostic factor for psoriasis susceptibility/severity and as a means for optimizing treatment response.
|
16385345 |
2006 |
|
Psoriasis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
VEGF levels may be regarded as a good indicator of active psoriasis arthritis.
|
17543159 |
2007 |
|
Psoriasis
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Vascular endothelial growth factor in patients with psoriatic arthritis.
|
17543159 |
2007 |
|
Psoriasis
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Single-nucleotide polymorphisms and haplotypes in the VEGF receptor 3 gene and the haplotype GC in the VEGFA gene are associated with psoriasis in Koreans.
|
18094729 |
2008 |
|
Psoriasis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of the CTG (-2578/-460/+405) haplotype within the vascular endothelial growth factor gene with early-onset psoriasis.
|
18937791 |
2008 |
|
Psoriasis
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Overexpression of vascular endothelial growth factor (VEGF) receptors on keratinocytes in psoriasis: regulated by calcium independent of VEGF.
|
18419602 |
2008 |
|
Psoriasis
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Single nucleotide polymorphisms of VEGF gene and Psoriasis risk.
|
18054203 |
2008 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Vascular endothelial growth factor (VEGF)-transgenic mice develop psoriasiform plaques that resemble human psoriasis, demonstrating that VEGF is an important factor in the development of psoriasis.
|
19659863 |
2009 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results imply that functional interactions among SP, IL-33, and mast cells leading to VEGF release contribute to inflammatory conditions, such as the psoriasis, a nonallergic hyperproliferative skin inflammatory disorder with a neurogenic component.
|
20160089 |
2010 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
BEFREE |
To date, no information has been acquired on the effectiveness of gene therapy for psoriasis in the K14-VEGF transgenic mouse model by topical transdermal penetration of murine IL-4 (mIL-4) using ultradeformable cationic liposome (UCL).
|
20527041 |
2010 |
|
Psoriasis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We have found significantly increased serum levels of VEGF in patients with psoriasis compared with those in healthy controls (P = 0.008).
|
22176586 |
2013 |
|
Psoriasis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Also, up-regulation of psoriasis-associated cytokine profiles, including VEGF, was inhibited in the skin from K14-Raf:ER;K5-Cre.Stat3(flox/flox) mice following 4OHT treatment.
|
23870655 |
2013 |
|
Psoriasis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
To examine the role of Notch-1 signalling in the pathogenesis of psoriasis, Notch-1, DLL-4, Jagged-1, Hrt-1/Hrt-2, A-SAA, Factor VIII and vascular endothelial growth factor (VEGF) mRNA and/or protein expression in psoriasis skin biopsies, serum and dHMVEC were assessed by immunohistology, dual-immunofluorescence, real-time PCR, ELISA and Western blotting.
|
24330353 |
2014 |
|
Psoriasis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In the current study, we assessed IL-37 in two well-known psoriasis models: a human keratinocyte cell line (HaCaT) and the keratin 14 VEGF-A-transgenic mouse model.
|
24453242 |
2014 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Vascular endothelial growth factor (VEGF), the most critical angiogenic factor, is thought to play important roles during the pathogenesis of psoriasis and may be a promising target for treating psoriasis.
|
25227750 |
2014 |
|
Psoriasis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Psoriasis (Ps) is an autoimmune disease characterized by keratinocyte hyperproliferation and chronic inflammation, with increased expression of tumor necrosis factor (TNF) and vascular endothelial growth factor (VEGF).
|
24587411 |
2014 |
|
Psoriasis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Results from the meta-analysis do support the hypothesis that single-nucleotide polymorphism markers at +405C>G, -460C>T, and -1154G>A of the VEGF gene may serve as biological markers of psoriasis.
|
24678886 |
2014 |