|
Psoriasis
|
0.600 |
Biomarker
|
disease |
MGD |
|
|
|
|
Psoriasis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Psoriasis (Ps) is an autoimmune disease characterized by keratinocyte hyperproliferation and chronic inflammation, with increased expression of tumor necrosis factor (TNF) and vascular endothelial growth factor (VEGF).
|
24587411 |
2014 |
|
Psoriasis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Vascular endothelial growth factor gene polymorphisms increase the risk to develop psoriasis.
|
16630077 |
2006 |
|
Psoriasis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
VEGF levels may be regarded as a good indicator of active psoriasis arthritis.
|
17543159 |
2007 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Vascular endothelial growth factor (VEGF)-transgenic mice develop psoriasiform plaques that resemble human psoriasis, demonstrating that VEGF is an important factor in the development of psoriasis.
|
19659863 |
2009 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Vascular endothelial growth factor (VEGF), the most critical angiogenic factor, is thought to play important roles during the pathogenesis of psoriasis and may be a promising target for treating psoriasis.
|
25227750 |
2014 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Vascular endothelial growth factor (VEGF), one of the downstream molecules of EGFR and TNF signaling, plays a key role in angiogenesis for developing psoriasis.
|
25384035 |
2014 |
|
Psoriasis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Vascular endothelial growth factor driving aberrant keratin expression pattern contributes to the pathogenesis of psoriasis.
|
28928080 |
2017 |
|
Psoriasis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Also, up-regulation of psoriasis-associated cytokine profiles, including VEGF, was inhibited in the skin from K14-Raf:ER;K5-Cre.Stat3(flox/flox) mice following 4OHT treatment.
|
23870655 |
2013 |
|
Psoriasis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Although increased expression of vascular endothelial growth factor protein was detected in the epidermis, the intensity of this staining was weak compared with the epidermal staining in psoriatic lesions and compared with the strong vascular endothelial growth factor mRNA signal in chronic wounds and psoriasis.
|
10886501 |
2000 |
|
Psoriasis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of the CTG (-2578/-460/+405) haplotype within the vascular endothelial growth factor gene with early-onset psoriasis.
|
18937791 |
2008 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
BEFREE |
At each step of the psoriasis molecular pathway, different inflammatory cytokines and angiogenic growth factors are involved such as hypoxia inducible factor-1 α (HIF-1 α), vascular endothelial growth factor (VEGF), matrix metalo proteinases (MMPs), basic fibroblast growth factor (bFGF), Angiopoitin-2, interleukin-8 (IL-8), IL-17, and IL-2.
|
28110689 |
2017 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Due to the effect of inhibiting production of VEGF, acitretin can effectively treat psoriasis.
|
31148871 |
2020 |
|
Psoriasis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Haplotype analysis suggests that the coexistence of the polymorphisms rs1799964 (TNF-α), rs2010963 (VEGF), rs833061 (VEGF), and rs6311 (5HT2A) may be a protective factor for psoriasis.
|
31148856 |
2020 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
BEFREE |
How relevant are vascular endothelial growth factor and intercellular adhesion molecule in the systemic capillary leak syndrome of psoriasis?
|
29364440 |
2018 |
|
Psoriasis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, two other VEGF SNPs, rs833061, and rs699947, showed no association with psoriasis susceptibility.
|
28803785 |
2017 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Immunostaining analyses in human psoriasis skin lesions and VEGF-A transgenic mouse skin suggested that the ectodomain shedding of LYVE-1 occurred in lymphatic vessels undergoing chronic inflammation.
|
26966180 |
2016 |
|
Psoriasis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In addition, VPF/VEGF is strongly expressed by epidermal keratinocytes in wound healing and psoriasis, disorders that are also characterized by increased microvascular permeability and angiogenesis.
|
7738351 |
1995 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In future, determination of VEGF gene polymorphisms and thus individual patient VEGF "signatures" may be used as a prognostic factor for psoriasis susceptibility/severity and as a means for optimizing treatment response.
|
16385345 |
2006 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
CTD_human |
In future, determination of VEGF gene polymorphisms and thus individual patient VEGF "signatures" may be used as a prognostic factor for psoriasis susceptibility/severity and as a means for optimizing treatment response.
|
16385345 |
2006 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
LHGDN |
In future, determination of VEGF gene polymorphisms and thus individual patient VEGF "signatures" may be used as a prognostic factor for psoriasis susceptibility/severity and as a means for optimizing treatment response.
|
16385345 |
2006 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In non-erythrodermic PF, VEGF positivity was similar to HI (P = 0.247), and lower than psoriasis (P = 0.049) and PV (P = 0.049).
|
29489039 |
2018 |
|
Psoriasis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In the current study, we assessed IL-37 in two well-known psoriasis models: a human keratinocyte cell line (HaCaT) and the keratin 14 VEGF-A-transgenic mouse model.
|
24453242 |
2014 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we assessed the therapeutic potential of IL-35 recombinant protein in three well-known mouse models: the dextransulfate sodium (DSS)-induced colitis mouse model, the keratin14 (K14)-vascular endothelial growth factor A (VEGF-A)-transgenic (Tg) psoriasis mouse model and the imiquimod (IMQ)-induced psoriasis mouse model.
|
29193791 |
2018 |
|
Psoriasis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this viewpoint study, the role of VEGF-mediated angiogenesis as a cause for cardiovascular events in patients with psoriasis is explored.
|
28156019 |
2017 |