|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The genetic aberrations of vascular endothelial growth factor (VEGF), mammalian target of rapamycin, Wnt signaling pathway, the inactivation of p53, Rb, WWOX genes, and amplification of APEX1, c-myc, RECQL4, RPL8, MDM2, VEGFA might be involved in the pathogenesis of osteosarcoma.
|
23666471 |
2013 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Strongly positive immunostaining for HIF-1a and VEGF were detectable in the nuclear and cytoplasm of osteosarcoma cells.
|
17310851 |
2006 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
VEGF blockade decelerates the growth of a murine experimental osteosarcoma.
|
18636145 |
2008 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Inhibition of VEGF may aid in treating osteosarcoma in clinic.
|
29257309 |
2018 |
|
Osteosarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
According to Cox regression analysis, the VEGF +1612A/G, -634G/C, and +936T/C polymorphisms did not statistically significantly increase the risk of overall survival of patients with osteosarcoma.
|
25966208 |
2015 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we screened an OS cell-specific aptamer (LC09) and developed a LC09-functionalized PEG-PEI-Cholesterol (PPC) lipopolymer encapsulating CRISPR/Cas9 plasmids encoding VEGFA gRNA and Cas9.
|
28938163 |
2017 |
|
Osteosarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The pooled results suggested that VEGF-2578C/A polymorphism was significantly associated with osteosarcoma risk in all genetic models as well as VEGF-634G/C polymorphism.
|
27144378 |
2017 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
It has been reported that VEGFR expression correlates with the outcome of patients with osteosarcoma and circulating VEGF level has been associated with the development of lung metastasis.
|
28656259 |
2017 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the function of HIF1 in osteosarcoma cells was further investigated in in-vitro experiments by regulating HIF1 and vascular endothelial growth factor-A (VEGF-A) expression.
|
26077139 |
2015 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cyr61 and VEGF expressions moderately correlated with each other in osteosarcoma, and exhibited significant association with Enneking stage and distant metastasis.
|
28647210 |
2017 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, VEGF-A expression correlates with clinical stages of osteosarcoma.
|
31719210 |
2019 |
|
Osteosarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our study suggests that the TT genotype of VEGF +936C/T genetic variants is associated with an increased risk of osteosarcoma.
|
26600515 |
2015 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Transfection of human osteosarcoma 9901 and HOS cells with pSilenceApe1 resulted in a dose-dependent loss of Ape1 protein. pSilenceApe1 also significantly suppressed the expression of vascular endothelial growth factor (VEGF) protein in the 9901 cells.
|
17892509 |
2007 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These effects were associated with decreased expression of Notch-1 and its downstream genes, such as vascular endothelial growth factor and matrix metalloproteinases, as well as increased expression of a panel of tumor-suppressive microRNAs (miRNAs), including miR-34a, miR-143, miR-145 and miR-200b/c that are typically lost in osteosarcoma.
|
23430952 |
2013 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we show that WISP-1 promotes VEGF-A expression in human osteosarcoma cells, subsequently inducing human endothelial progenitor cell (EPC) migration and tube formation.
|
28406476 |
2017 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The authors report for the first time that VEGF pathway genes, including the VEGFA gene, are amplified in osteosarcoma.
|
21495021 |
2011 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, knockdown of CCL5 suppressed VEGF expression and attenuated osteosarcoma CM-induced angiogenesis in vitro and in vivo.
|
25330803 |
2015 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study, a significant correlation was found between ADM and VEGF expression in the plasma of osteosarcoma patients.
|
30890367 |
2019 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, we detected the expression of vascular endothelial growth factor (VEGF) and signal transducer and activator of transcription 3 (STAT3) in osteosarcoma cell treated with Eag1 small interfering RNAs (siRNAs).
|
26783521 |
2015 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
For the first time, we demonstrated that IGF1 3'UTR increased VEGF expression and promotes angiogenesis in osteosarcoma cells.
|
26759259 |
2016 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the results showed that vascular endothelial growth factor (VEGF) expression was down-regulated in osteosarcoma cells after miR-145 transfection.
|
22472569 |
2012 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study shows that CCL3 promotes VEGF-A expression and angiogenesis in human osteosarcoma cells by down-regulating miR-374b expression via JNK, ERK, and p38 signaling pathways.
|
26713602 |
2016 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found that serum concentrations of CXCL8 and vascular endothelial growth factor were elevated in osteosarcoma patients in comparison with those in NCs.
|
28736978 |
2017 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The study demonstrates potent growth and pulmonary metastasis inhibitory effects of VEGF-siRNA on osteosarcoma in vivo and in vitro, which could potentially be applicable to the treatment of cancers as an antiangiogenic therapeutic in the near future.
|
19409047 |
2009 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Chondrosarcoma, Ewing's Sarcoma and Osteosarcoma are the tumours of the musculoskeletal system in which the activity of VEGF has been closely studied.
|
31169001 |
2019 |