|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
WWOX promoted apoptosis and inhibited invasion and expression of bcl-2, OPN, RUNX2, and VEGF in osteosarcoma cells <i>in vitro</i>.
|
28977834 |
2017 |
|
Osteosarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analysis of previously published OS aCGH data (GSE9654) and aCGH data from this study (GSE19180) identified significant deletion of WWOX in 30% (6/20) of OS samples, whilst significant increase in both RUNX2 and VEGFA gene copy numbers were detected in 55% (11/20) and 60% (12/20) of OS samples, respectively.
|
24330824 |
2013 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Future studies should examine the relationship between VEGF isoform expression and patients' survival and the relationship between VEGF isoform expression and EMMPRIN expression, which could be helpful for predicting the prognosis of patients with osteosarcoma.
|
22274866 |
2012 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased vascular endothelial growth factor (VEGF) expression in osteosarcoma correlates with a poor outcome.
|
28631382 |
2017 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Prognostic significance of VEGF expression in osteosarcoma: a meta-analysis.
|
23907576 |
2014 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that autocrine VEGF/VEGFR1 signaling in a subpopulation of tumor cells plays a pivotal role in osteosarcoma progression.
|
24759089 |
2014 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
1,25-(OH)2D3 increased the steady-state levels of VEGF mRNA in a time- and concentration-dependent manner in HObLC and one of the osteosarcoma cell lines, SaOS-2, accompanied by an increase in the concentration of immunoreactive VEGF in the conditioned medium.
|
8992878 |
1996 |
|
Osteosarcoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
In vitro, depletion of SH3GL1 abrogates P130<sup>cas</sup> phosphorylation and IL-6- and VEGF-induced OS cell proliferation and migration.
|
28702842 |
2017 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the OS cell lines, growth in a pressurized environment was associated with VEGF-A downregulation, VEGF-C upregulation, and TPA upregulation.
|
18473395 |
2008 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In summary, it was demonstrated that miRNA-638 expression change in patients with osteosarcoma and an <i>in vitro</i> model via PLD1 and VEGF expression and miRNA-638 may be potential clinical indicators of osteosarcoma.
|
30988774 |
2019 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Importantly, knockdown IL-6 reduced VEGF expression and abolished osteosarcoma conditional medium-mediated angiogenesis.
|
23219526 |
2013 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We identified 12 SNVs in CTLA-4, IL-8, MDM2, PRCKG, RECQL5, TNF-a, TP53, XRCC3, and VEGF that correlated with osteosarcoma susceptibility.
|
30235774 |
2018 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
However, the regulation of the VEGF/VEGFR1 expression is still unclear in OS.
|
29474747 |
2018 |
|
Osteosarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In sum, our meta-analysis suggests VEGF polymorphisms are associated with osteosarcoma susceptibility in the Chinese population.
|
27351225 |
2016 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Spearman's correlation analysis was utilized to examine the relationship between miR‑944 and VEGF expression levels, and rescue experiments were applied to further verify whether VEGF mediates the role of miR‑944 in OS.
|
30280196 |
2018 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to investigate the expression levels of Caveolin-1 and VEGF in osteosarcoma and their associations with clinicopathological data.
|
31676993 |
2019 |
|
Osteosarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, our study showed that the AA and CA+AA genotypes of the VEGF -2578C/A polymorphism might modify the risk of osteosarcoma in a Chinese population.
|
26400284 |
2015 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
AUF1 positively controls angiogenesis through mRNA stabilization-dependent up-regulation of HIF-1α and VEGF-A in human osteosarcoma.
|
31448053 |
2019 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This was associated with a decrease in VEGF (vascular endothelial growth factor) and SDF-1 (stromal derived factor-1) on the protein level, both related to the control of angiogenesis and furthermore discussed as crucial factors in osteosarcoma progression and metastasis.
|
28632184 |
2017 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Amentoflavone significantly inhibits tumor growth and reduces protein levels of phospho-extracellular signal-regulated kinase (P-ERK), nuclear factor-kappaB (NF-κB) p65 (Ser536), vascular endothelial growth factor (VEGF), matrix metallopeptidase 9 (MMP-9), X-linked inhibitor of apoptosis protein (XIAP), and cyclin-D1 in osteosarcoma in vivo.
|
31262893 |
2019 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We also found that miR-410 was lowly expressed and inversely correlated with VEGF expression in OS specimens.
|
25385479 |
2015 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Besides, miR-29b directly targets VEGF and over-expression of miR-29b led to down-regulation of VEGF protein level, In conclusions, miR-29b may play an important role in osteosarcoma progression, which might negatively regulate the expression of VEGF and suppresses proliferation and induces apoptosis of MG63 cell line.
|
25337211 |
2014 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our results suggest that Eag1 silencing inhibits tumor growth and angiogenesis in osteosarcoma via the down regulation of VEGF/PI3K/AKT signaling.
|
23202914 |
2012 |
|
Osteosarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of EWS/Fli-1 using siRNA on a Ewing's sarcoma cell line (A673) suppressed VEGF-A expression, and transfection of EWS/Fli-1 into a human osteosarcoma cell line increased VEGF-A expression.
|
19642105 |
2010 |
|
Osteosarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
TfR1 and VEGF are potential prognostic factors for osteosarcoma.
|
31484533 |
2019 |