|
Malignant tumor of colon
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although the VEGF -2578C > A polymorphism had no influence on susceptibility to colon cancer, some genotypes showed a significant difference between the case and control groups when the data were stratified by gender and the original location of tumor, suggesting that the VEGF -2578C > A polymorphism, at least in Koreans, is a genetic determinant of colon cancer risk.
|
17695550 |
2007 |
|
Malignant tumor of colon
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
After stratifying by tumor molecular subtype, SNP associations observed for colon cancer were: VEGFA rs2010963 with CIMP+ colon tumors; FLT1 rs4771249 and rs7987649 with TP53; FLT1 rs3751397, rs7337610, rs7987649, and rs9513008 and KDR rs10020464, rs11941492, and rs12498529 with MSI+ and CIMP+/KRAS2-mutated tumors.
|
23794399 |
2014 |
|
Malignant tumor of colon
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We wished to demonstrate vascular endothelial growth factor (VEGF) transcript polymorphism in human colon cancer.
|
12209585 |
2002 |
|
Malignant tumor of colon
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Further studies are needed to understand the mechanism of VEGF gene polymorphisms in the development and progression of colon cancer.
|
21091242 |
2011 |
|
Malignant tumor of colon
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Of the gene-environment combined effects, the interaction of VEGF 1451C > T and MetS contributed to increased rectal cancer risk (AOR = 3.15; 95% CI = 1.74 - 5.70; p < .001) whereas the combination of VEGF 1725G > A and MetS was involved with elevated colon cancer risk (AOR = 2.68; 95% CI = 1.30 - 1.55; p =0.008).
|
25423914 |
2014 |
|
Malignant tumor of colon
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that the VEGF 936C>T polymorphism might be a genetic determinant for colon cancer, at least in Koreans.
|
18505065 |
2008 |
|
Malignant tumor of colon
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
According to our results, -1154 G/A and -460 C/T do not influence VEGF mRNA expression in colorectal tumors and susceptibility to sporadic colon cancer, although the role of other polymorphisms cannot be excluded.
|
18613756 |
2008 |
|
Malignant tumor of colon
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings suggest that TAC-101 may inhibit progression and metastasis in colon cancer by interfering with tumor production of VEGF.
|
15490972 |
2004 |
|
Malignant tumor of colon
|
0.600 |
Biomarker
|
disease |
RGD |
Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1α and VEGF.
|
21268133 |
2011 |
|
Malignant tumor of colon
|
0.600 |
Biomarker
|
disease |
BEFREE |
To analyze the biological activities of these VEGF isoforms on tumor growth, we transfected human VEGF121, VEGF165 or VEGF189 cDNA into the human colon cancer cell line SW-480, and established several clones overexpressing these VEGF isoforms.
|
12429975 |
2002 |
|
Malignant tumor of colon
|
0.600 |
Biomarker
|
disease |
BEFREE |
These studies demonstrate that the IGF ligand-receptor system plays an important role in multiple mechanisms that mediate human colon cancer growth including regulation of VEGF and angiogenesis.
|
12374697 |
2002 |
|
Malignant tumor of colon
|
0.600 |
Biomarker
|
disease |
BEFREE |
A gene signature comprising LAMA1, ITGB1, ITGA2, CXCR4 and VEGFA has negative predictive value in colon cancer.
|
29907957 |
2018 |
|
Malignant tumor of colon
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aim was to investigate the predictive value of postoperative VEGF serum concentration in patients undergoing surgery for colon cancer.
|
28683891 |
2018 |
|
Malignant tumor of colon
|
0.600 |
Biomarker
|
disease |
BEFREE |
A stable VEGF gene-transfected human colon cancer cell line, LoVo, was made by genetic manipulation using eukaryotic expression constructs designed to express the complete VEGF121 cDNA in the sense orientation.
|
10690548 |
2000 |
|
Malignant tumor of colon
|
0.600 |
Biomarker
|
disease |
CTD_human |
Polymorphisms in IL1B, IL1RN, and VEGFA as well as IL1B/IL1RN haplotype analysis may serve as molecular markers for tumor recurrence in stage II colon cancer, indicating that the analysis of angiogenesis-related gene polymorphisms may help to identify patient subgroups at high risk for tumor recurrence.
|
18987561 |
2009 |
|
Malignant tumor of colon
|
0.600 |
Biomarker
|
disease |
BEFREE |
Vascular endothelial growth factor (VEGF) is implicated in the angiogenesis of human colon cancer.
|
9422768 |
1998 |
|
Malignant tumor of colon
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our previous studies demonstrated that mutant KRAS alleles can interact with hypoxia to induce vascular endothelial growth factor (VEGF) in colon cancer.
|
20532039 |
2010 |
|
Malignant tumor of colon
|
0.600 |
Biomarker
|
disease |
BEFREE |
The secretion of vascular endothelial growth factor (VEGF) was inhibited by single PTX treatment of colon cancer and in continuous treatment of glioblastoma cell lines.
|
21775090 |
2011 |
|
Malignant tumor of colon
|
0.600 |
Biomarker
|
disease |
BEFREE |
Vascular endothelial growth factor (VEGF) is a potent angiogenic factor important for colon cancer neovascularization.
|
10519388 |
1999 |
|
Malignant tumor of colon
|
0.600 |
Biomarker
|
disease |
BEFREE |
PTHrP treatment of colon cancer cells promotes tumor associated-angiogenesis by the effect of VEGF.
|
30639585 |
2019 |
|
Malignant tumor of colon
|
0.600 |
Biomarker
|
disease |
BEFREE |
Whereas the inhibition of vascular endothelial growth factor (VEGF) has shown promising results in sporadic colon cancer, the role of VEGF signaling in colitis-associated cancer (CAC) has not been addressed.
|
21098094 |
2010 |
|
Malignant tumor of colon
|
0.600 |
Biomarker
|
disease |
BEFREE |
Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis.
|
7535799 |
1995 |
|
Malignant tumor of colon
|
0.600 |
Biomarker
|
disease |
BEFREE |
Furthermore, we revealed that VEGF is one of the molecules which are responsible for metastasis and prognosis in esophageal cancer and colon cancer.
|
10457902 |
1999 |
|
Malignant tumor of colon
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings suggest the existence of multiple mechanisms regulating the hypoxic induction of VEGF in colon cancer.
|
14996738 |
2004 |
|
Malignant tumor of colon
|
0.600 |
Biomarker
|
disease |
BEFREE |
Collectively, these findings suggest an alternative mechanism for the hypoxic induction of VEGF in colon cancer that does not depend upon HIF-1alpha but instead requires the activation of PI3K/Rho/ROCK and c-Myc.
|
16543245 |
2006 |