|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Clinical and preclinical studies have demonstrated that depression, one of the most common psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF), contributing to neuronal atrophy in the prefrontal cortex (PFC) and hippocampus, and reduced hippocampal adult neurogenesis.
|
31830487 |
2020 |
|
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The patients with depression showed lower mean VEGF levels in the CSF prior to ECT than the controls (p = 0.041).
|
31103810 |
2019 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Overall, our results indicate that the measurement of VEGF protein is not a useful marker for depression or response to treatment, and suggest that the measurement of VEGFA mRNA may prove more useful.
|
29968119 |
2018 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The present study demonstrated that miR-27a expression in hippocampal tissues and blood from rats with depression is upregulated, while the expression of VEGFA mRNA and protein is downregulated. miR-27a may participate in the pathological process of depression in rats by regulating VEGFA.
|
29731825 |
2018 |
|
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These behaviors were associated with an increase 5-HT and DA neurotransmitter content, as well as an increase of VEGF levels in the hippocampus of the post-MI depression rats.
|
29574217 |
2018 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
This novel association reveals new molecular mechanisms suggesting the potential role of VEGF in depression development that could help to promote a personalized prediction for this severe common disease.
|
28267147 |
2017 |
|
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
159 individuals including PSD, stroke without depression (Non-PSD), major depressive disorder (MDD) and normal control groups were recruited and examined the protein and mRNA expression levels of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptors (VEGFR2), placental growth factor (PIGF), insulin-like growth factor (IGF-1) and insulin-like growth factor receptors (IGF-1R).
|
27527872 |
2016 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF.
|
26556286 |
2015 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Induction of proteinuria by cannabinoid receptors 1 signaling activation in CB1 transgenic mice.
|
25474224 |
2015 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The genetic marker rs10434 was significantly associated with depression after correction for multiple testing, but not with the serum VEGF level.
|
24636631 |
2014 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Elevated levels of vascular endothelial growth factor (VEGF) are observed in conditions with vessel and neuron damage or pathological arborization and can therefore be detected in chronic inflammatory process, cardiovascular disease and depression.
|
24718046 |
2014 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
A higher VEGF concentration may play a potentially significant role in the pathogenesis of depression, and the expression level appears to be unaffected by additional factors.
|
24718046 |
2014 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
However, only a few studies have investigated serum VEGF levels in individuals with depression, or the possible association between genetic variants within the VEGF gene and depression.
|
24636631 |
2014 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Limited information related to the role of VEGFA gene polymorphism in depressive disorder is available.
|
23673188 |
2013 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Limited information related to the role of VEGFA gene polymorphism in depressive disorder is available.
|
23673188 |
2013 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
In this study, we have observed that Nrf2 deletion in mice results in: (i) a depressive-like behavior evaluated as an increase in the immobility time in the tail-suspension test and by a decrease in the grooming time in the splash test, (ii) reduced levels of dopamine and serotonin and increased levels of glutamate in the prefrontal cortex, (iii) altered levels of proteins associated to depression such as VEGF and synaptophysin and (iv) microgliosis.
|
23623252 |
2013 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent research findings suggest that vascular endothelial growth factor (VEGF) participates in the development of depressive disorder.
|
23164459 |
2013 |
|
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Chronic stress decreases neurotrophin levels, precipitating or exacerbating depression; conversely, antidepressants increase expression of various neurotrophins (e.g., brain-derived neurotrophic factor and vascular endothelial growth factor), thereby blocking or reversing structural and functional pathologies via promoting neurogenesis.
|
19423950 |
2009 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The cAMP cascade and vascular endothelial growth factor (VEGF) are critical modulators of depression.
|
19571140 |
2009 |