Hyperglycemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, the transcutaneous CO<sub>2</sub> attenuated a decrease in capillary and the expression level of eNOS and VEGF protein, and an increase in the expression level of MDM-2 and TSP-1 protein of soleus muscle due to STZ-induced hyperglycemia.
|
30478742 |
2019 |
Hyperglycemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Furthermore, CGRP suppressed the increased HIF-1α/VEGF-A expression and the phosphorylation of ERK1/2 in hyperglycemia.
|
31487015 |
2019 |
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings demonstrate that insulin prevents hyperglycemia-induced pulmonary vascular leakage in diabetic mice by inhibiting VEGF-induced TGase2 activation rather than ROS generation.
|
31374233 |
2019 |
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
RasGRP1 is involved in the VEGF-induced angiogenesis and the pro-angiogenesis effects of metformin under hyperglycemia.
|
31120617 |
2019 |
Hyperglycemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Elevated expression of photoreceptor-secreted RBP3 may have a role in protection against the progression of DR due to hyperglycemia by inhibiting glucose uptake via GLUT1 and decreasing the expression of inflammatory cytokines and VEGF.
|
31270273 |
2019 |
Hyperglycemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hyperglycemia invoke number of pathways resulting in development of diabetic retinopathy (DR), including protein kinase C activation, increased expression of VEGF, advanced glycation end product (AGEs) formation and activation of polyol pathway, among which the pathophysiology of aldose reductase (ALR2) of the polyol pathway is evident by more than a decade of research.
|
30551523 |
2019 |
Hyperglycemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased VEGF levels were consistent in diabetic retinas and ARPE-19 tissue culture cells cultured under hyperglycemia.
|
30980286 |
2019 |
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our light-microscopic data showed remarkable re-distribution of VEGF in proximal tubular cells (PTCs) during prolonged hyperglycemia, a DM type 2 model (DM2), which was confirmed by transmission electron microscopy (TEM) findings.
|
29804263 |
2018 |
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overall, we presented how IH application has a beneficial cardiovascular remodeling effect in left ventricular function of diabetic rats, at most, via affecting increased oxidative stress and HIF-VEGF related angiogenesis, providing information on hyperglycemia associated new targets and therapeutic strategies.
|
29615543 |
2018 |
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings indicate that hyperglycaemia leads to a reduction in the VEGF-A/VEGFR2 signalling cascade, resulting in endothelial dysfunction in the spinal cord, which could be an undiscovered contributing factor to diabetic neuropathic pain.
|
29774557 |
2018 |
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hyperglycemia and intraocular vascular endothelial growth factor (VEGF) over-accumulation are essential for the progression of diabetic retinopathy, which eventually results in proliferative diabetic retinopathy, characterized by pathologic angiogenesis and impaired vision.
|
29203232 |
2018 |
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hyperglycemia Alters the Protein Levels of Prominin-1 and VEGFA in the Retina of Albino Rats.
|
29076766 |
2018 |
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hyperglycemia induced Egr-1 and vascular endothelial growth factor-A (VEGF-A) but not pigment epithelium derived factor (PEDF) in hRECs.
|
29307595 |
2018 |
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hyperglycemia mediated oxidative stress and pro-angiogenic molecules such as vascular endothelial growth factor (VEGF) and matrix metalloproteinase 9 (MMP9) are considered important for diabetic retinopathy onset and progression.
|
29890158 |
2018 |
Hyperglycemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Metformin promoted HUVEC migration and inhibited apoptosis via upregulation of vascular endothelial growth factor (VEGF) receptors (VEGFR1/R2), fatty acid binding protein 4 (<i>FABP4</i>), ERK/mitogen-activated protein kinase signaling, chemokine ligand 8, lymphocyte antigen 96, Rho kinase 1 (<i>ROCK1</i>), matrix metalloproteinase 16 (<i>MMP16</i>) and tissue factor inhibitor-2 under hyperglycemia-chemical hypoxia.
|
29351188 |
2018 |
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, we used Western blot to analyze the mechanism of hyperglycemia-induced testicular VEGF decrease.
|
29435181 |
2018 |
Hyperglycemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results indicate that HIF1α is as an upstream modulator of ROS in peripheral sensory neurons and exerts a protective function in suppressing hyperglycemia-induced nerve damage by limiting ROS levels and by inducing expression of VEGF which may promote peripheral nerve survival.
|
30361814 |
2018 |
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
VEGF-A<sub>165</sub>b prevented VEGF-A<sub>165</sub>a and hyperglycaemia-induced tight junction (TJ) breakdown and subsequent increase in solute flux in RPE cells.
|
28341661 |
2017 |
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Alteration of pro- and antiangiogenic homeostasis of vascular endothelial growth factor (VEGF) isoforms in patients with hyperglycemia seems crucial but substantially unexplored at least quantitatively for diabetic retinopathy (DR).
|
28680264 |
2017 |
Hyperglycemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Treatment of hyperglycemia with insulin reduced VEGF levels and retinal swelling, consistent with the idea that VEGF is an important factor in postischemic swelling and that good glycemic control following AION may lead to better visual outcome.
|
28431433 |
2017 |
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to explore the effects of hyperglycemia on fibroblast growth factor 2 (FGF2)- and vascular endothelial growth factor (VEGF)-stimulated placental angiogenesis and the underlying molecular signaling mechanisms.
|
27606810 |
2016 |
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aimed to determine the differences in the localization and expression level of VEGFA and VEGFR2 between placentas of women with GDM and placentas of normal pregnancies, which is the first step in elucidating the possible roles of VEGFA and VEGFR2 in the altered uteroplacental function resulting from maternal hyperglycaemia and ultimately in the manifestation of GDM.
|
27645229 |
2016 |
Hyperglycemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Metformin increased in vitro angiogenesis under hyperglycemia-hypoxia and augmented the expression of VEGFA.
|
26861446 |
2016 |
Hyperglycemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we examined the effect glucagon-induced hyperglycemia on tumor growth as well as the role of the hypoxia-inducible factor 1 (HIF-1)-vascular endothelial growth factor (VEGF) pathway in this condition.
|
25222223 |
2014 |
Hyperglycemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, MDA-MB-231BR cells showed a unique sensitivity to hypo/hyperglycemia in terms of morphological changes, colony formation ability, integrin β3 expression and secreted VEGF levels.
|
25401697 |
2014 |