VEGFA, vascular endothelial growth factor A, 7422

N. diseases: 1899; N. variants: 59
Disease: Angiogenic Switch ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1510885
Disease: Angiogenic Switch
Angiogenic Switch 		0.100 AlteredExpression disease BEFREE Mechanistic investigations revealed that failure of the angiogenic switch could be attributed to reduced Vegfa mRNA and protein expression in VECs, a source of VEGFA mRNA in the tumor that was limiting in the absence of myeloid WNT7B. 24638982 2014
CUI: C1510885
Disease: Angiogenic Switch
Angiogenic Switch 		0.100 AlteredExpression disease BEFREE Hu antigen R is associated with the upregulation of VEGF-A and COX-2 mRNA in TECs, and has an important role in keeping an angiogenic switch on, through activating angiogenic phenotype in tumour endothelium. 21285980 2011
CUI: C1510885
Disease: Angiogenic Switch
Angiogenic Switch 		0.100 AlteredExpression disease BEFREE We conclude that tasquinimod-induced up-regulation of TSP1 is part of a mechanism involving down-regulation of HIF1alpha and VEGF, which in turn leads to reduced angiogenesis via inhibition of the "angiogenic switch", that could explain tasquinimods therapeutic potential. 20470445 2010
CUI: C1510885
Disease: Angiogenic Switch
Angiogenic Switch 		0.100 AlteredExpression disease BEFREE These data show that disrupting cytostructure activates the angiogenic switch even in the absence of proliferation and/or hypoxia and restoring organization of malignant clusters reduces VEGF expression and EC activation to levels found in quiescent nonmalignant epithelium. 19654314 2009
CUI: C1510885
Disease: Angiogenic Switch
Angiogenic Switch 		0.100 AlteredExpression disease BEFREE However, ERKs reduce the VEGF mRNA-destabilizing effect of TTP, leading to an increase in VEGF expression that favors the angiogenic switch. 17855506 2007
CUI: C1510885
Disease: Angiogenic Switch
Angiogenic Switch 		0.100 Biomarker disease BEFREE Angiogenic switch in Barrett's adenocarcinoma: the role of vascular endothelial growth factor. 16720317 2006
CUI: C1510885
Disease: Angiogenic Switch
Angiogenic Switch 		0.100 Biomarker disease BEFREE The induction of tumor dormancy correlated with an angiogenic switch caused by a decreased production of vascular endothelial growth factor and an increase in the production of the angiogenesis inhibitor thrombospondin-1. 16205646 2006
CUI: C1510885
Disease: Angiogenic Switch
Angiogenic Switch 		0.100 Biomarker disease BEFREE Transient induction of the transcription factor early growth response protein-1 (EGR-1) plays a pivotal role in the transcriptional response of endothelial cells to the angiogenic growth factors vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), which are produced by most tumors and are involved in the angiogenic switch. 16818645 2006
CUI: C1510885
Disease: Angiogenic Switch
Angiogenic Switch 		0.100 AlteredExpression disease BEFREE Together, these data indicate that a disruption of the balance between VEGF and TSP-1 expression leads to a UVB-induced angiogenic switch, facilitating the infiltration of elastase-producing leucocytes and cutaneous photodamage. 15656811 2005
CUI: C1510885
Disease: Angiogenic Switch
Angiogenic Switch 		0.100 Biomarker disease BEFREE MMP-9, a proangiogenic protease implicated in mobilization of VEGF, appeared in the stroma concomitant with the angiogenic switch, expressed by infiltrating macrophages, similar to what has been observed in humans. 15343380 2004
CUI: C1510885
Disease: Angiogenic Switch
Angiogenic Switch 		0.100 Biomarker disease BEFREE Together, our findings identify Shc as a critical angiogenic switch for VEGF production downstream from the Met and ErbB2 RTKs. 14983012 2004
CUI: C1510885
Disease: Angiogenic Switch
Angiogenic Switch 		0.100 Biomarker disease BEFREE The aim of this study was to determine the role and timing of the VEGF angiogenic switch during CRC progression. 12754739 2003
CUI: C1510885
Disease: Angiogenic Switch
Angiogenic Switch 		0.100 Biomarker disease BEFREE The decrease in VEGF-D occurring in polyps and carcinomas may allow the higher levels of VEGF-A and VEGF-C to bind more readily to the VEGF receptors, and produce the angiogenic switch required for tumor growth. 11687953 2002
CUI: C1510885
Disease: Angiogenic Switch
Angiogenic Switch 		0.100 AlteredExpression disease BEFREE We characterize the angiogenic switch, which occurs during the transition from preinvasive lesions to invasive carcinoma in this model, and which is accompanied by a significant increase in total protein levels of vascular endothelial growth factor (VEGF) and an invasion of blood vessels. 12209972 2002