|
Vascular endothelial growth factor overexpression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Similar levels of VEGF overexpression are found in astrocytes, neurons, and vascular endothelial cells, which suggest that VEGF may be derived from astrocytes and neurons.
|
29191115 |
2018 |
|
Vascular endothelial growth factor overexpression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
VEGF overexpression and/or high VEGF serum levels have been reported in lung cancer.
|
28831824 |
2017 |
|
Vascular endothelial growth factor overexpression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Based on subgroup analysis by study location, number of patients, the source of VEGF expression, and study design, we found that VEGF overexpression in surgically resected tissue (HR = 1.95, 95% CI: 1.41-2.69, P = 0.000), but not in serum (HR = 1.37, 95% CI: 0.96-1.95, P = 0.087), was associated with poorer prognosis.
|
25810565 |
2015 |
|
Vascular endothelial growth factor overexpression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
VEGF expression was significantly higher in hypopharyngeal squamous cell carcinoma tissues (74.00%) than in normal hypopharyngeal tissues (30.00%; P = 0.002), VEGF overexpression differed significantly across different pathologic grades and different T stages, and regarding the presence of cervical lymph node metastasis (P < 0.05).
|
25158264 |
2014 |
|
Vascular endothelial growth factor overexpression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To investigate the prognostic significance of VEGF overexpression in adult AML, we performed a meta-analysis of the published studies that provided survival information according to VEGF expression status.
|
23157271 |
2013 |
|
Vascular endothelial growth factor overexpression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, in addition to the cytotoxic action on the A-431 cells, mTHPC-mediated PDT stimulated the production of VEGF and IL-1alpha, and IL-1alpha contributed to the VEGF overexpression.
|
22171990 |
2012 |
|
Vascular endothelial growth factor overexpression
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, withdrawal of estrogen from the tumors resulted in increased VEGF and elevated vascular permeability, presumably due to hypoxic conditions that were found to dominate VEGF overexpression in cultured cells.
|
19398483 |
2009 |
|
Vascular endothelial growth factor overexpression
|
0.100 |
Biomarker
|
disease |
BEFREE |
To study the effect of VEGF overexpression on development of cortical newborn neurons in the brains after stroke, we injected human VEGF(165)-expressive plasmids (phVEGF) into the lateral ventricle of rat brains with a transient middle cerebral artery occlusion (MCAO).
|
19540294 |
2009 |
|
Vascular endothelial growth factor overexpression
|
0.100 |
Biomarker
|
disease |
BEFREE |
We further demonstrated that forced VEGF overexpression or autocrine VEGF stimulation of VEGFR-2 triggers proliferation and migration/invasion of U-937 leukemic cells, thereby inducing a more invasive tumor phenotype.
|
18987662 |
2009 |
|
Vascular endothelial growth factor overexpression
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that extraamniotic VEGF overexpression lowered the systemic blood pressure without altering the VEGF concentration in the peripheral blood.
|
17075769 |
2006 |
|
Vascular endothelial growth factor overexpression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Severe combined immunodeficient mice bearing xenografts of transfected cell lines were used to assess the effect of VEGF overexpression and the effect of VEGF receptor (VEGFR) 2 inhibition on STS growth, metastasis, and response to doxorubicin.
|
16951193 |
2006 |
|
Vascular endothelial growth factor overexpression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A review of relevant published literature regarding VEGF, von Hippel-Lindau (VHL) gene inactivation, and VEGF overexpression in RCC was performed.
|
15793222 |
2005 |
|
Vascular endothelial growth factor overexpression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data demonstrate that VEGF protects neurons from ischaemic cell death by a direct action rather than by promoting angiogenesis, and suggest that strategies aiming at increasing vascular density in the whole brain, e.g. by VEGF overexpression, may worsen rather than improve cerebral haemodynamics after stroke.
|
15509618 |
2005 |
|
Vascular endothelial growth factor overexpression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A review of relevant published literature regarding VEGF, von Hippel-Lindau (VHL) gene inactivation and VEGF overexpression in RCC was performed.
|
15534359 |
2005 |
|
Vascular endothelial growth factor overexpression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cotreatment with VEGF-trap completely sequestered free VEGF and abrogated the beneficial effect of VEGF overexpression.
|
15477421 |
2004 |
|
Vascular endothelial growth factor overexpression
|
0.100 |
Biomarker
|
disease |
BEFREE |
MVD was correlated with COX-2 and VEGF overexpression (P=0.009 and P=0.003, respectively), COX-2 and VEGF were correlated to one another (P=0.044).
|
14719060 |
2004 |
|
Vascular endothelial growth factor overexpression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, VEGF gene transfer into rabbit carotid arteries using the hemagglutinating virus of Japan (HVJ)-liposomes showed that VEGF overexpression could induce the angiomatoid proliferation.
|
10805284 |
2000 |
|
Vascular endothelial growth factor overexpression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
VEGF overexpression occurs in most human malignancies including thyroid carcinomas in which elevated VEGF expression is associated with a high tumorigenic potential.
|
10490819 |
1999 |
|
Vascular endothelial growth factor overexpression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these data demonstrate that wt-VHL, by neutralizing PKC isoforms zeta and delta and thereby inhibiting MAPK activation, plays an important role in preventing aberrant VPF/VEGF overexpression and the angiogenesis that results from such overexpression.
|
9346879 |
1997 |