|
Lymphatic Metastasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Expression of a CD44 variant and VEGF-C and the implications for lymphatic metastasis and long-term prognosis of human breast cancer.
|
15943035 |
2005 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent evidence suggests that tumor production of vascular endothelial growth factor-C (VEGF-C) promotes lymphagiogenesis, which in turn promotes lymphatic metastasis.
|
16489074 |
2006 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pathway-related molecules of VEGFC/D-VEGFR3/NRP2 axis in tumor lymphangiogenesis and lymphatic metastasis.
|
27527412 |
2016 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent findings demonstrate that the bioactive lipid lysophosphatidic acid (LPA) promotes PCa progression by regulating vascular endothelial growth factor-C (VEGF-C), a critical mediator of tumor lymphangiogenesis and lymphatic metastasis.
|
30384405 |
2018 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Vascular endothelial growth factor-C (VEGF-C) is the most potent and selective lymphangiogenic factor that plays a crucial role in the establishment of the first lymphatic vessel during embryonic development and in mediating lymphatic metastasis.
|
17904785 |
2007 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We concluded that pSTAT3, which was a risk factor of prognosis, was abnormally expressed in pancreatic adenocarcinoma and related to tumor size, TNM staging and lymphatic metastasis. pSTAT3 may promote tumor angiogenesis via up-regulating VEGF on protein and even gene levels, and enhance the early lymphatic metastasis through VEGF-C.
|
22082308 |
2012 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Vascular endothelial growth factor C (VEGF-C) and its receptor, VEGFR-3, have been implicated as important factors in the formation of lymphatic vessels and recent evidence suggests that tumor lymphangiogenesis promotes lymphatic metastasis.
|
15880525 |
2005 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
LHGDN |
VEGF-C plays a role in lymphatic metastasis via lymphangiogenesis and angiogenesis in ESCC.
|
16874878 |
2006 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We suggest that BDNF may serve as a promising therapeutic target for the restriction of VEGF-C-mediated tumor lymphangiogenesis and lymphatic metastasis.
|
28771226 |
2017 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Vascular endothelial growth factor-C (VEGF-C) is the major lymphangiogenic factor, and makes crucial contributions to tumour lymphangiogenesis and lymphatic metastasis.
|
27252405 |
2016 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, the biological experiments showed that PELI2 could promote the growth and metastasis of GC cells by regulating vascular endothelial growth factor C. Our study indicates that the identified 28-gene signature could be considered as a sensitive predictive tool for lymphatic metastasis in GC.
|
30971501 |
2019 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
CXCR4 and VEGF-C might synergically promote lymphatic metastasis in lung cancer and might be a clinical predictor of lymph node metastasis in NSCLC patients.
|
28925100 |
2017 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of cyclooxygenase-2 in gastric cancer correlates with the high abundance of vascular endothelial growth factor-C and lymphatic metastasis.
|
16260857 |
2005 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aims to detect the difference in expression between survivin and vascular endothelial growth factor-C (VEGF-C) in treated breast cancer cells and tissues, and to analyze the correlation among survivin, VEGF-C and lymphatic metastasis.
|
22607367 |
2012 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings indicate that eNOS mediates VEGF-C-induced lymphangiogenesis and, consequently, plays a critical role in lymphatic metastasis.
|
19318557 |
2009 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
As lymphangiogenesis has been implicated in stimulation of lymphatic metastasis by vascular endothelial growth factor-C (VEGF-C) and VEGF-D, we studied the effect of the angioregulatory growth factor angiopoietin-2 (Ang-2) on PDAC progression.
|
21685330 |
2011 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results indicate that lentivirus-mediated VEGF-C siRNA offers a new approach for therapeutic intervention to prevent tumor growth and lymphatic metastasis of breast cancer.
|
19382240 |
2009 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Survivin, a multifunctionale molecule involved in apoptosis, proliferation and angiogenesis, and vascular endothelial growth factor-C (VEGF-C) are suggested to be implicated in lymphatic metastases of human malignancies.
|
29578160 |
2018 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
VEGF-C plays a role in lymphatic metastasis via lymphangiogenesis and angiogenesis in ESCC.
|
16874878 |
2006 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Vascular endothelial growth factor-C (VEGF-C) is the major lymphangiogenic factor, and makes crucial contributions to tumor lymphangiogenesis and lymphatic metastasis.
|
27166194 |
2016 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show that VEGF-C produced by tumor cells induced extensive lymphatic sprouting towards the tumor cells as well as dilation of the draining lymphatic vessels, suggesting an active role of lymphatic endothelial cells in lymphatic metastasis.
|
15930292 |
2005 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study suggests that both VEGF-C and VEGF-D are involved in peritumoral lymphangiogenesis and lymphatic metastasis.
|
18561194 |
2008 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lymphatic metastasis is facilitated by lymphangiogenic growth factors VEGF-C and VEGF-D that are secreted by some primary tumors.
|
22340592 |
2012 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Vascular endothelial growth factor-C (VEGF-C), which contributes to lymphatic metastasis (LM) in malignant disease, is one of the most important factors involved in physical and pathological lymphangiogenesis.
|
24716913 |
2014 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the expression of HGF‑α or c‑Met was closely correlated with VEGF‑C, LMVD and metastases of lymph nodes, indicating that HGF‑α, c‑Met and VEGF‑C may perform important and collaborative actions in lymphangiogenesis and lymphatic metastasis of primary NSCLC.
|
25504327 |
2015 |