|
Lymphatic Metastasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, blocking the lectin‑like oxLDL‑1 (LOX‑1) receptor, a specific receptor for oxLDL, and the nuclear factor (NF)‑κB signaling pathway following oxLDL (50 µg/ml) treatment in HGC‑27 cells revealed that oxLDL could activate the NF‑κB signaling pathway mediated by LOX‑1, with subsequent upregulation of VEGF‑C expression, and secretion in and from gastric cancer cells, and finally that it could promote the lymphatic metastasis of gastric cancer.
|
30483757 |
2019 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, the biological experiments showed that PELI2 could promote the growth and metastasis of GC cells by regulating vascular endothelial growth factor C. Our study indicates that the identified 28-gene signature could be considered as a sensitive predictive tool for lymphatic metastasis in GC.
|
30971501 |
2019 |
|
Lymphatic Metastasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Activation of VEGF-C/VEGFR3 signaling in lymphatic endothelial cells (LECs) was shown to enhance the proliferation of LECs and the formation of lymphatic vessels, leading to increased lymphatic metastasis of tumor cells.
|
30901976 |
2019 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent findings demonstrate that the bioactive lipid lysophosphatidic acid (LPA) promotes PCa progression by regulating vascular endothelial growth factor-C (VEGF-C), a critical mediator of tumor lymphangiogenesis and lymphatic metastasis.
|
30384405 |
2018 |
|
Lymphatic Metastasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The fact that FOXF2 controls the activation of the VEGF-C/VEGFR3 signaling pathway in BLBC cells provides potential molecular diagnostic and therapeutic strategies for lymphatic metastasis in BLBC patients.
|
29409810 |
2018 |
|
Lymphatic Metastasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data indicate that TNFSF15, a cytokine mainly produced by blood endothelial cells, facilitates tumor lymphangiogenesis by upregulating VEGFC expression in A549 cells, contributing to lymphatic metastasis in tumor-bearing mice.
|
29890027 |
2018 |
|
Lymphatic Metastasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mechanically, kallistatin suppressed the lymphangiogenesis and lymphatic metastasis by downregulating VEGF-C expression and secretion through the LRP6/IKK/IҡB/NF-ҡB signaling pathway in gastric cancer cells.
|
29243194 |
2018 |
|
Lymphatic Metastasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, the correlation between SRC-1 and VEGFC levels in the lymphatic metastases of thyroid cancer remains unclear.
|
29717026 |
2018 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Survivin, a multifunctionale molecule involved in apoptosis, proliferation and angiogenesis, and vascular endothelial growth factor-C (VEGF-C) are suggested to be implicated in lymphatic metastases of human malignancies.
|
29578160 |
2018 |
|
Lymphatic Metastasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
VEGF-C expression attributes the risk for lymphatic metastases to ovarian cancer patients.
|
28591727 |
2017 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We suggest that BDNF may serve as a promising therapeutic target for the restriction of VEGF-C-mediated tumor lymphangiogenesis and lymphatic metastasis.
|
28771226 |
2017 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
CXCR4 and VEGF-C might synergically promote lymphatic metastasis in lung cancer and might be a clinical predictor of lymph node metastasis in NSCLC patients.
|
28925100 |
2017 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pathway-related molecules of VEGFC/D-VEGFR3/NRP2 axis in tumor lymphangiogenesis and lymphatic metastasis.
|
27527412 |
2016 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Vascular endothelial growth factor-C (VEGF-C) is the major lymphangiogenic factor, and makes crucial contributions to tumour lymphangiogenesis and lymphatic metastasis.
|
27252405 |
2016 |
|
Lymphatic Metastasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MTA1 is up-regulated in CRC.MTA1 expression is inversely associated with lymphatic metastases and the expression of VEGFC, VEGFD and VEGFR3.
|
26543080 |
2016 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Vascular endothelial growth factor-C (VEGF-C) is the major lymphangiogenic factor, and makes crucial contributions to tumor lymphangiogenesis and lymphatic metastasis.
|
27166194 |
2016 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the expression of HGF‑α or c‑Met was closely correlated with VEGF‑C, LMVD and metastases of lymph nodes, indicating that HGF‑α, c‑Met and VEGF‑C may perform important and collaborative actions in lymphangiogenesis and lymphatic metastasis of primary NSCLC.
|
25504327 |
2015 |
|
Lymphatic Metastasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Results showed that MMP-2 and VEGF-C expression levels in the PTs and MMP-2, MMP-21 and VEGF-C expression in the LNM foci correlated with the overall survival of the OSCC patients with lymphatic metastasis.
|
24700287 |
2014 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Vascular endothelial growth factor-C (VEGF-C), which contributes to lymphatic metastasis (LM) in malignant disease, is one of the most important factors involved in physical and pathological lymphangiogenesis.
|
24716913 |
2014 |
|
Lymphatic Metastasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate the correlation between the expression of survivin and vascular endothelial growth factor‑C (VEGF‑C) in gastric cancer and the pathway by which survivin may affect gastric cancer lymphatic metastasis.
|
24337012 |
2014 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We concluded that pSTAT3, which was a risk factor of prognosis, was abnormally expressed in pancreatic adenocarcinoma and related to tumor size, TNM staging and lymphatic metastasis. pSTAT3 may promote tumor angiogenesis via up-regulating VEGF on protein and even gene levels, and enhance the early lymphatic metastasis through VEGF-C.
|
22082308 |
2012 |
|
Lymphatic Metastasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aims to detect the difference in expression between survivin and vascular endothelial growth factor-C (VEGF-C) in treated breast cancer cells and tissues, and to analyze the correlation among survivin, VEGF-C and lymphatic metastasis.
|
22607367 |
2012 |
|
Lymphatic Metastasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
468LN cells differentially express α9β1 integrin, a receptor for lymphangiogenic factors VEGF-C/-D. We explored whether (1) differential production of VEGF-C/-D by 468LN cells provides an autocrine stimulus for cellular motility by interacting with α9β1 and a paracrine stimulus for lymphangiogenesis in vitro as measured with capillary-like tube formation by human lymphatic endothelial cells (HMVEC-dLy); (2) differential expression of α9 also promotes cellular motility/invasiveness by interacting with macrophage derived factors; (3) stable knock-down of VEGF-D or α9 in 468LN cells abrogates lymphangiogenesis and lymphatic metastasis in vivo in nude mice.
|
22545097 |
2012 |
|
Lymphatic Metastasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In summary, our study indicates that nuclear twist plays an important role in ESCC lymphatic metastasis by increasing the expression of VEGF-C.
|
22441818 |
2012 |
|
Lymphatic Metastasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of VEGF-C/VEGFR-3 in human laryngeal squamous cell carcinomas and its significance for lymphatic metastasis.
|
22502683 |
2012 |