VEGFC, vascular endothelial growth factor C, 7424

N. diseases: 291; N. variants: 12
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease BEFREE <b>Conclusion:</b> In conclusion, rapamycin suppresses angiogenesis and lymphangiogenesis in melanoma by blocking the mTOR signal pathway and subsequently downregulating the expression of VEGF-A/VEGFR-2 and VEGF-C/VEGFR-3. 31354297 2019
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease BEFREE The melanoma lines differed substantially in the expression of VEGF-A, VEGF-C, and platelet-derived growth factor A. Sunitinib treatment reduced vessel densities and induced hypoxia in all melanoma lines, and the magnitude of the effect was associated with the gene expression and protein secretion rate of VEGF-A. 28167241 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease BEFREE PD-1/PD-L1 and VEGF-A/VEGF-C expression in lymph node microenvironment and association with melanoma metastasis and survival. 28984690 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE This study aimed to examine the role of quantitative parameters of tumour lymphangiogenesis and vascular endothelial growth factor (VEGF)-C in predicting metastatic risk in patients with cutaneous melanoma. 28756123 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease BEFREE Screening of a set of independently isolated melanoma cell lines from other patients confirmed this association between expression of high levels of MET and of VEGF-C and PDGF-C. 22570180 2012
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease BEFREE Concomitant overexpression of VEGF-C or feeding of animals with CsA restored lymphangiogenesis and metastasis in Wnt1(+) melanoma. 22572818 2012
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Univariate and multivariate analyses indicated that VEGF-C and VEGF-D were independent prognostic factors for overall survival and disease-free survival in patients with malignant melanoma. 18561194 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease LHGDN VEGF-C expression in melanoma cells was predictive of a shorter overall and disease-free survival, without being an independent predictor of survival. 18679715 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease CTD_human VEGF-C might be involved in the deep lymphatic dissemination and progression of melanoma metastasis. 17562445 2007
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease BEFREE Melanoma tumor cell sublines established from lymph node metastasis express higher amounts of VEGF-C than the parental tumor cells. 16061674 2005
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease BEFREE Vertical growth phase melanomas expressed significantly higher levels of VEGF-C than horizontal growth phase melanomas. 14676121 2003
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease BEFREE VEGF-C expression was evaluated in vitro on human melanoma cell lines established from cutaneous and lymph node metastasis specimens by reverse transcriptase-polymerase chain reaction, Northern blot analysis, and immunofluorescence analysis. 12910524 2003
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease LHGDN Vertical growth phase melanomas expressed significantly higher levels of VEGF-C than horizontal growth phase melanomas. 14676121 2003