Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Spinally, the IL/mGluR5-induced behavioral heat hyperalgesia is mediated by TRPV1 and associated with facilitated heat-evoked responses of WDR and NS neurons.
|
28300633 |
2017 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
TRPV1 was responsible from the cisplatin-induced heat hyperalgesia and mechanical allodynia in the sensory neurons.
|
29326595 |
2017 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Ablation of TRPV1-expressing fibers prevented facial hyperalgesia in diabetic rats.
|
28606782 |
2017 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
It has been revealed that TRPM8 activation leads to a decline in TRPV1 activity, which may be of therapeutic benefit in clinical circumstances such as treatment of TRPV1-mediated inflammatory hyperalgesia, colitis, and dry eye syndrome.
|
28861042 |
2017 |
Hyperalgesia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
To analyze the contribution of TRPV1 to the development of vincristine-induced mechanical allodynia/hyperalgesia, TRPV1 expression in the rat dorsal root ganglion (DRG) was analyzed after vincristine treatment.
|
28410966 |
2017 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Transient receptor potential vanilloid sub‑type 1 (TRPV1) play an important role in the development of allodynia and hyperalgesia following injury and the ensuing inflammatory conditions.
|
29369297 |
2017 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons.
|
27916453 |
2016 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Moxibustion relieves visceral hyperalgesia via inhibition of transient receptor potential vanilloid 1 (TRPV1) and heat shock protein (HSP) 70 expression in rat bone marrow cells.
|
26338695 |
2016 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
A strong connection has been suggested between the expression of the transient receptor potential vanilloid type 1 (TRPV1) ion channel and the development of inflammatory hyperalgesia.
|
26176938 |
2015 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Following TNBS treatment, the successive administration of the transient receptor potential vanilloid 1 (TRPV1) antagonist SB366791 or neutralizing anti-Artn antibody completely inhibited the heat hyperalgesia.
|
26270588 |
2015 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Altogether, these results indicate that B vitamins can be useful to control heat hyperalgesia associated with trigeminal neuropathic pain and that modulation of TRPV1 receptors may contribute to their anti-hyperalgesic effects.
|
26048309 |
2015 |
Hyperalgesia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Notably, intrathecal administration of the interfering peptide against the phosphorylation of Thr-406 alleviated heat hyperalgesia and reduced the surface level of TRPV1 in inflammatory pain rats.
|
26376215 |
2015 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Importantly, we found that interfering with TRPV1 subunit association using a plasma membrane-tethered peptide attenuated mechanical and thermal hypersensitivity in two mouse models of inflammatory hyperalgesia.
|
24808184 |
2014 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Taken together, these findings demonstrate that TRPV1 is a locus for cross sensitization between AITC and heat in sensory neurons and may help explaining, at least in part, the role of this channel in AITC-induced hyperalgesia to heat.
|
23955021 |
2014 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that antagonizing the TRPV1-AKAP79 interaction will be a useful strategy for inhibiting inflammatory hyperalgesia.
|
23699529 |
2013 |
Hyperalgesia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
In summary, our results demonstrate an increased activity of TRPV1 in DRG neurons as a new mechanism contributing to opioid withdrawal-induced hyperalgesia.
|
23398938 |
2013 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Pretreatment with ketoconazole inhibited the release of TRPV1 agonists in lipid extracts from inflamed skin and significantly reversed CFA-induced heat hyperalgesia by a peripheral mechanism of action.
|
23006841 |
2012 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
RGD |
Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study.
|
21958434 |
2011 |
Hyperalgesia
|
0.600 |
PosttranslationalModification
|
phenotype |
BEFREE |
Phosphorylation of TRPV1, involving Protein Kinase C (PKC) and Protein Kinase A (PKA), appears to be the predominant mechanism for channel sensitization and development of heat hyperalgesia.
|
20043876 |
2010 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Because animals treated with opiates show thermal hyperalgesia, we examined the possible role of TRPV1 receptors in the development of morphine-induced hyperalgesia using TRPV1 wild-type (WT) and knock-out (KO) mice and with administration of a TRPV1 antagonist in mice and rats.
|
18774343 |
2009 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Because TRPV1 and TRPA1 channels play important roles in controlling hyperalgesia in inflammatory pain models, we investigated their modulation by WIN and AM1241.
|
18234885 |
2008 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
LHGDN |
These data provide the first clinical evidence that a TRPV1 antagonist may alleviate pain and hyperalgesia associated with inflammation and tissue injury.
|
17659837 |
2007 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
LHGDN |
Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice.
|
16793902 |
2006 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
That a proinflammatory chemokine, by interacting with its receptor on small-diameter neurons, sensitizes TRPV1 reveals a previously undescribed mechanism of receptor cross-sensitization that may contribute to hyperalgesia during inflammation.
|
15764707 |
2005 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.
|
15128844 |
2004 |