|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Induction of TRPV1 expression may be an important mechanism underlying the increased risks for asthma after exposure to environmental pollutants.
|
30708321 |
2019 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TRPV1 mRNA levels were significantly increased in CRSwNP patients with asthma and allergic rhinitis compared to their NP counterparts.
|
29476616 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study examined whether TRPV1 antagonism alleviates asthma features in a murine model of chronic asthma.
|
29676068 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, we show that prophylactic administration of TRPV1 (AMG9810) and LPA (BrP-LPA) receptor antagonists prevents bradykinin-induced asthmatic bronchoconstriction and, if administered following allergen exposure, reduces the associated respiratory distress.
|
30279412 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Metabolic shifts in mild asthma, relative to controls, were associated with exogenous metabolites (<i>e.g.</i> dietary lipids), while those in moderate and severe asthma (<i>e.g.</i> oleoylethanolamide, sphingosine-1-phosphate, N-palmitoyltaurine) were postulated to be involved in activating the transient receptor potential vanilloid type 1 (TRPV1) receptor, driving TRPV1-dependent pathogenesis in asthma.Our findings suggest that asthma is characterised by a modest systemic metabolic shift in a disease severity-dependent manner, and that steroid treatment significantly affects metabolism.
|
28356371 |
2017 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To investigate the effects of particulate matter ≤ 2.5 microns (PM2.5) on asthma-related phenotypes and on lung expression of TRPA1 and TRPV1 proteins in a mouse model of asthma.
|
28102732 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mediating Role of TRPV1 Ion Channels in the Co-exposure to PM2.5 and Formaldehyde of Balb/c Mice Asthma Model.
|
28931832 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our purpose was to investigate the regulatory mechanism of TRPV1 and related cytokines on children bronchial asthma.
|
28386183 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Characterization of Transient Receptor Potential Vanilloid-1 (TRPV1) Variant Activation by Coal Fly Ash Particles and Associations with Altered Transient Receptor Potential Ankyrin-1 (TRPA1) Expression and Asthma.
|
27758864 |
2016 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TRPV1 mRNA level of peripheral blood in the asthma group was higher than that in the control group before treatment (p < 0.01).
|
25715236 |
2015 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The levels of TRPV1 gene expression and Th1/Th2 cytokines have a close relationship with asthma onset in children, which provides theoretical evidences for molecular targeted treatment in children with bronchial asthma.
|
25585038 |
2015 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Quantitative immunohistochemistry revealed significantly more TRPV1 expression in asthmatic patients compared with healthy subjects, with the greatest expression in patients with refractory asthma (P = .001).
|
24210884 |
2014 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Blocking of 13-S-HODE activity or disruption of TRPV1 activity attenuated airway injury and asthma mimicking features in murine allergic airway inflammation.
|
23443229 |
2013 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since TRPV1 expression is correlated with human asthma severity, TRPV1 inhibition could be beneficial in attenuating airway epithelial injury and asthma features.
|
23453702 |
2013 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that TRPV1 can be expressed on bronchial fibroblasts in situations where an underlying inflammatory stimulus exists, as is the case in airway diseases such as asthma and COPD.
|
22242698 |
2012 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TRPV1 SNPs were associated with cough among subjects without asthma from two independent studies in eight European countries.
|
22443337 |
2012 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data suggest that genetically determined level of TRPV1 activity is relevant for asthma pathophysiology.
|
20639579 |
2010 |