|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Beneficial effect of mirtazapine on diabetes-induced hyperalgesia: involvement of TRPV1 and ASIC1 channels in the spinal cord and dorsal root ganglion.
|
30822229 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although TRPV1 expressing neuron percentage was increased in <i>Ins2<sup>+/Akita</sup></i> DRGs at 9 months of diabetes compared to control, capsaicin-induced Ca<sup>2+</sup> influx was smaller in isolated <i>Ins2<sup>+/Akita</sup></i> DRG neurons, indicating impaired TRPV1 function.
|
30795543 |
2019 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The transient receptor potential vanilloid 1 (TRPV1) channel plays a central role in such sensory abnormalities and shows elevated expression levels in animal models of diabetes.
|
29474476 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, given its plausible involvement in regulation of energy and glucose homeostasis and its dysregulation in obesity, TRPV1 may be a target for weight loss therapy and diabetes.
|
30108548 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Capsaicin is an agonist of the transient receptor potential vanilloid type 1 (TRPV1) channel, which has been related to the pathophysiology of kidney disease secondary to diabetes.
|
30583465 |
2018 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TRPV1 alterations in urinary bladder dysfunction in a rat model of STZ-induced diabetes.
|
29100756 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to better characterize the actions of MEL and Se in diabetes-induced peripheral pain and hippocampal injury through modulation of TRPM2 and TRPV1, we tested the effects of MEL and Se on apoptosis and oxidative stress in the hippocampal and dorsal root ganglion (DRG) neurons of streptozotocin (STZ)-induced diabetic rats.
|
26957303 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results show the first evidence of an amino acid specific modification of TRPV1 by 4-HNE suggesting this 4-HNE-dependent modification of TRPV1 may contribute to microvascular dysfunction and tissue perfusion deficits characteristic of diabetes.
|
27682362 |
2016 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
People with the minor alleles of the TRPV1 single nucleotide polymorphisms rs161364 and rs8065080 have a lower risk of diabetes with a high-fat diet, but people with the major alleles are at a higher risk of type 2 diabetes when consuming high-fat diets.
|
27287034 |
2016 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We argue that TRPV1 agonists and antagonists are not mutually exclusive but rather complimentary pharmacologic approaches for pain relief and we predict a "revival" for capsaicin and other TRPV1 agonists in the clinical management of pain associated with inflammation, metabolic imbalances (eg, diabetes), infections (HIV), and cancer, despite the current focus of the pharmaceutical industry on TRPV1 antagonists.
|
18209521 |
2008 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We argue that TRPV1 antagonists alone or in conjunction with other analgesics will improve the quality of life of people with migraine, chronic intractable pain secondary to cancer, AIDS or diabetes.
|
17464295 |
2007 |