Disease: Neuralgia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE Parkinson's disease (PD) related pain can be assigned to either nociceptive pain or neuropathic pain, in which Transient receptor potential vanilloid 1 (TRPV1) has been demonstrated to play a pivotal role. 31708101 2020
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain. 30609840 2019
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE Based on these results, silencing of the TRPV1 gene in the spinal cord attenuates the maintenance of neuropathic pain by inhibiting CAMKII/ERK2 activation and suggests that TRPV1 represents a potential target in pain therapy. 30808963 2019
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE Although it is known that the transcription of TRPV1 is regulated by Kruppel-like zinc-finger transcription factor 7 (Klf7)-and that the structure of TRPV1 is similar to that of Kv-few studies have systematically investigated the relationship between MZF1 and TRPV1 in neuropathic pain. 31582966 2019
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 AlteredExpression phenotype BEFREE Our study provides fundamental evidence that chronic inflammation and neuropathic pain models amplify the release of glutamate through the activation of TRPV1 in central axon terminals, and that facilitation of TRPV1 function in rat spinal SG neurons may contribute to enhanced capsaicin-induced inward currents. 31493465 2019
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE Accumulating evidence suggests that the transient receptor potential vanilloid 1 (TRPV1) was involved in the development of neuropathic pain and hyperalgesia. 30863139 2019
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE SZV 1287 inhibits chronic inflammatory and neuropathic pain via TRPV1 and TRPA1/TRPV1 activation, respectively, highlighting its drug developmental potential. 29438782 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE Our findings show the involvement of both TRPA1 and TRPV1 channels in trigeminal neuropathic pain, and in particular, in trigeminal mechanical allodynia. 30366396 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 AlteredExpression phenotype BEFREE These results suggest that puerarin dose-dependently ameliorates neuropathic pain by suppressing Trpv1 and Trpa1 up-regulation in dorsal root ganglion of neuropathic pain rats. 30028336 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 AlteredExpression phenotype BEFREE Selective inhibition of TRPV1 activity in primary sensory neurons by DRG delivery of AAV-encoded analgesic interfering peptide aptamers is efficacious in attenuation of neuropathic pain. 28604222 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE Long Non-coding RNA BC168687 is Involved in TRPV1-mediated Diabetic Neuropathic Pain in Rats. 29421435 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE This study demonstrated dual mechanisms of neuropathic pain in TRPV1-induced neuropathy, involving a reduced adenosine system at both the ligand (adenosine) and receptor (A1Rs) levels. 29672450 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE Although TRPV1 plays an important role in neuropathic pain, the mechanism of how TRPV1 was regulated in neuropathic pain remains unclear. 29808083 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE We hypothesized that the antinociceptive effect of OT on neuropathic pain may occur via inhibition of TRPV1 activation in the spinal cord. 30065629 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE Together, our study demonstrates a novel mechanism underlying the analgesic effect of zinc on paclitaxel-induced neuropathic pain that relies on the function of TRPV1.<b>SIGNIFICANCE STATEMENT</b> The chemotherapy-induced peripheral neuropathy is a major limiting factor affecting the chemotherapy patients. 29192128 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 AlteredExpression phenotype BEFREE The amelioration of neuropathic pain by berberine may be associated with the down-regulation of TRPV1 in DRG of neuropathic pain rats. 30168114 2018
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 GeneticVariation phenotype BEFREE It was suggested that the TRPV1-variant rs8065080 (1911A>G) plays a pivotal role in patients with neuropathic pain syndromes. 28817717 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE Transient receptor potential vanilloid 1 (TRPV1) plays a crucial role in neuropathic pain and influences the plasticity of neuronal connectivity. 28740739 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE Sciatic nerve injury (SNI) results in neuropathic pain, which is characterized by the excessive Ca<sup>2+</sup> entry, reactive oxygen species (ROS) and apoptosis processes although involvement of antioxidant <i>Hypericum perforatum</i> (HP) through TRPM2 and TRPV1 activation has not been clarified on the processes in SNI-induced rat, yet. 28620309 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE Analgesic effect of coumarins from Radix angelicae pubescentis is mediated by inflammatory factors and TRPV1 in a spared nerve injury model of neuropathic pain. 27915078 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE TRPM2 and TRPV1 have been shown to be involved in induction of neuropathic pain. 28097492 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE TRPV1 is known to play an important role in the pathogenesis of inflammatory and neuropathic pain states. 28831207 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE These results further substantiated the role of spinal TRPV1 receptors in the development of paclitaxel-induced neuropathic pain and contribute to better understanding of the pathological mechanisms involved. 28730839 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 Biomarker phenotype BEFREE Altogether, these results indicate that B vitamins can be useful to control heat hyperalgesia associated with trigeminal neuropathic pain and that modulation of TRPV1 receptors may contribute to their anti-hyperalgesic effects. 26048309 2015
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.100 AlteredExpression phenotype BEFREE TRPV1 is both activated and sensitized by inflammatory endogenous mediators during inflammatory pain conditions and appears to be up regulated in neuropathic pain conditions. 22104468 2012