Disease: Pain, Burning ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0234230
Disease: Pain, Burning
Pain, Burning 		0.340 GeneticVariation phenotype BEFREE The sensitivities to burning pain and capsaicin of Japanese adult subjects were compared with their TRPV1 genome sequence, and we detected 6 single-nucleotide polymorphisms and 11 single-nucleotide polymorphisms related to burning pain and capsaicin sensitivity, respectively. 30209980 2019
CUI: C0234230
Disease: Pain, Burning
Pain, Burning 		0.340 AlteredExpression phenotype BEFREE When expressed by sensory neurons, activation of TRPV1 channels by heat (>40 °C), capsaicin (sub-micromolar), or acid environment (pH < 6), causes depolarization leading to burning pain sensation in mammals. 31026506 2019
CUI: C0234230
Disease: Pain, Burning
Pain, Burning 		0.340 Biomarker phenotype BEFREE Capsaicin is an ingredient in spicy peppers that produces burning pain by activating transient receptor potential vanilloid 1 (TRPV1), a Ca<sup>2+</sup>-permeable ion channel in nociceptors. 28360106 2017
CUI: C0234230
Disease: Pain, Burning
Pain, Burning 		0.340 Biomarker phenotype BEFREE Such polymodal-sensor aspect makes the TRPV1 channel extremely versatile and important for its role in sensing burning pain. 27038373 2016
CUI: C0234230
Disease: Pain, Burning
Pain, Burning 		0.340 Therapeutic phenotype CTD_human The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. 23006841 2012
CUI: C0234230
Disease: Pain, Burning
Pain, Burning 		0.340 Biomarker phenotype CTD_human The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. 23006841 2012
CUI: C0234230
Disease: Pain, Burning
Pain, Burning 		0.340 Biomarker phenotype CTD_human Tumor tissue-derived formaldehyde and acidic microenvironment synergistically induce bone cancer pain. 20422007 2010
CUI: C0234230
Disease: Pain, Burning
Pain, Burning 		0.340 Therapeutic phenotype CTD_human Tumor tissue-derived formaldehyde and acidic microenvironment synergistically induce bone cancer pain. 20422007 2010
CUI: C0234230
Disease: Pain, Burning
Pain, Burning 		0.340 Therapeutic phenotype CTD_human Surfactant-induced TRPV1 activity--a novel mechanism for eye irritation? 17575321 2007
CUI: C0234230
Disease: Pain, Burning
Pain, Burning 		0.340 Biomarker phenotype CTD_human Surfactant-induced TRPV1 activity--a novel mechanism for eye irritation? 17575321 2007
CUI: C0234230
Disease: Pain, Burning
Pain, Burning 		0.340 Biomarker phenotype CTD_human Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo. 16996476 2006
CUI: C0234230
Disease: Pain, Burning
Pain, Burning 		0.340 Therapeutic phenotype CTD_human Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo. 16996476 2006