Disease: Visceral Pain ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0234245
Disease: Visceral Pain
Visceral Pain 		0.100 Biomarker phenotype BEFREE Mast cells (MCs), PAR2 and TRPV1, play a key role in the regulation of visceral pain. 30560330 2019
CUI: C0234245
Disease: Visceral Pain
Visceral Pain 		0.100 Biomarker phenotype BEFREE Our findings indicate that the spinal mGluR5-TRPV1 pathway modulates nociceptive transmission in uterine cervical distension-induced pathological visceral pain. 30444177 2019
CUI: C0234245
Disease: Visceral Pain
Visceral Pain 		0.100 Biomarker phenotype BEFREE Here, we hypothesize that in parallel with TRPV1, histamine sensitizes TRPA1 and TRPV4, contributing to increased visceral pain in patients with IBS. 30629470 2019
CUI: C0234245
Disease: Visceral Pain
Visceral Pain 		0.100 AlteredExpression phenotype BEFREE Secondary outcomes are Visceral Pain Scale and levels of TRPV1 and microRNA-199 in colonic tissues. 29794793 2018
CUI: C0234245
Disease: Visceral Pain
Visceral Pain 		0.100 AlteredExpression phenotype BEFREE Visceral pain is initiated by activation of primary afferent neurons among which the capsaicin-sensitive (TRPV1-positive) neurons play an important role. 29275446 2018
CUI: C0234245
Disease: Visceral Pain
Visceral Pain 		0.100 Biomarker phenotype BEFREE Endocannabinoid anandamide (AEA) inhibits intestinal motility and visceral pain, but it may also be proalgesic through transient receptor potential vanilloid-1 (TRPV1). 28695708 2017
CUI: C0234245
Disease: Visceral Pain
Visceral Pain 		0.100 Biomarker phenotype BEFREE Previous studies indicated that P2Y1 and P2Y2 receptors, which are widely distributed in the enteric nervous system, are related to pain, while TRPV1 may contribute to visceral pain and hypersensitivity states in irritable bowel syndrome (IBS). 27250983 2016
CUI: C0234245
Disease: Visceral Pain
Visceral Pain 		0.100 AlteredExpression phenotype BEFREE Gut miR-199a/b expression in IBS-D was significantly decreased, which correlated directly with both increased visceral pain scores and TRPV1 expression. 25681400 2016
CUI: C0234245
Disease: Visceral Pain
Visceral Pain 		0.100 Biomarker phenotype BEFREE TRPV1 sensitization mediates postinflammatory visceral pain following acute colitis. 26021808 2015
CUI: C0234245
Disease: Visceral Pain
Visceral Pain 		0.100 Biomarker phenotype BEFREE The transient receptor potential vanilloid 1 (TRPV1) channel, which is involved in visceral pain signalling, has been shown to be up-regulated in IBS. 23529955 2013
CUI: C0234245
Disease: Visceral Pain
Visceral Pain 		0.100 Biomarker phenotype BEFREE Therefore, we aimed to investigate whether neomycin can inhibit in vivo TRPV1-dependent hypersensitivity responses in two rat models of visceral pain. 19298229 2009