|
Agnosia for Pain
|
0.100 |
Biomarker
|
disease |
BEFREE |
They also suggest that CB1 and TRPV1 receptors are important for CBD-induced analgesia and that CBD could produce these analgesic effects increasing endogenous anandamide levels.
|
31706993 |
2020 |
|
Agnosia for Pain
|
0.100 |
Biomarker
|
disease |
BEFREE |
Primary sensory neuron cultures also were treated with the latex extract or vehicle for 15 min followed by stimulation with the TRPV1 agonist capsaicin.Results showed that <i>E. bicolor</i> latex extract evoked significant pain behaviors in both male and female rats at 20 min post-injection and lasting around 1-2 h. At 6 h post-injection, analgesia was observed in male rats that lasted up to 4 weeks, whereas in females the onset of analgesia was delayed to 72 h post-injection.
|
31551772 |
2019 |
|
Agnosia for Pain
|
0.100 |
Biomarker
|
disease |
BEFREE |
LLLT analgesia is mediated by the antinociceptive signaling of intramuscular substance P and is associated with TRPV1 activation in a mouse model of fibromyalgia or chronic muscle pain.
|
30908578 |
2019 |
|
Agnosia for Pain
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using the complete Freund's adjuvant (CFA) inflammatory pain model to examine the role of TRPV1 in regulating endogenous opioid analgesia in mice, we found that naloxone methiodide (Nal-M), a peripherally restricted, nonselective, and competitive opioid receptor antagonist, slowed the recovery from CFA-induced hypersensitivity in wild-type, but not TRPV1-deficient, mice.
|
30940767 |
2019 |
|
Agnosia for Pain
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to discover a novel type of analgesic, we investigated dual activity ligands with TRPV1 antagonism and mu-opioid receptor affinity with the goal of eliciting synergistic analgesia while avoiding the side effects associated with single targeting.
|
31472474 |
2019 |
|
Agnosia for Pain
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HF and IBA at 0.1 μg promoted analgesia in neurogenic and inflammatory phases of formalin test, against glutamate-induced nociception and independent of the activation of endogenous opioidergic system and dependent of TRPV1 modulation, whereas only HF reduced both nociception and mast cell degranulation in hindpaw induced by compound 48/80.
|
30414462 |
2018 |
|
Agnosia for Pain
|
0.100 |
Biomarker
|
disease |
BEFREE |
One approach for TRPV1 analgesia is to target TRPV1 along the peripheral sensory pathway.
|
28604222 |
2018 |
|
Agnosia for Pain
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aimed to investigate the involvement of MrgprC and its transient receptor potential vanilloid 1 (TRPV1) pathway in EA analgesia in chronic inflammatory pain.
|
29619074 |
2018 |
|
Agnosia for Pain
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The anandamide reuptake inhibitor N-arachidonoylaminophenol (AM404) and the reactive substance N-acetyl-p-benzoquinone imine (NAPQI) are both metabolites of acetaminophen and may contribute to acetaminophen-induced analgesia by acting at TRPV1 expressed in the peripheral or central nervous system.
|
29273526 |
2018 |
|
Agnosia for Pain
|
0.100 |
Biomarker
|
disease |
BEFREE |
We hypothesized that the water extraction of frankincense and myrrh (WFM) exerted its analgesia effect by modulating the neuronal function of TRPV1.
|
28740739 |
2017 |
|
Agnosia for Pain
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that local injection of the TRPV1 agonist resiniferatoxin (RTX) would produce long-lasting analgesia in a rat model of pain associated with burn injury.
|
27794548 |
2017 |
|
Agnosia for Pain
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice that had been i.c.v.-administered RTX also exhibited normal nociceptive responses in the formalin test and the tail pressure test, but acetaminophen failed to induce analgesia in those mice in any of the tests.These results suggest that i.c.v. administration of RTX leads to brain-selective TRPV1 desensitization in mice.
|
28963471 |
2017 |
|
Agnosia for Pain
|
0.100 |
Biomarker
|
disease |
BEFREE |
While TRPV1 does not seem to mediate acetaminophen-induced hepatotoxicity, our data identify TRPV1 as a target of acetaminophen with a potential relevance for acetaminophen-induced analgesia, antipyresia and inflammation.
|
28986540 |
2017 |
|
Agnosia for Pain
|
0.100 |
Biomarker
|
disease |
BEFREE |
TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists.
|
16971522 |
2006 |