|
Cirrhosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The von Willebrand Factor antigen to platelet ratio (VITRO) score predicts hepatic decompensation and mortality in cirrhosis.
|
31832759 |
2019 |
|
Cirrhosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Plasma vWF levels correlated with Child's score, model for end-stage liver disease (MELD) score and hepatic venous pressure gradient and performed as well as MELD score in predicting mortality in patients with cirrhosis and ACLF.
|
31498279 |
2019 |
|
Cirrhosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Role of the von Willebrand factor and the VITRO score as predictors for variceal bleeding in patients with hepatitis C-related cirrhosis.
|
30281535 |
2019 |
|
Cirrhosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The data indicate that both VWF release and processing of active VWF are increased in cirrhosis, reflecting ongoing wound healing initiation.
|
30768435 |
2019 |
|
Cirrhosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elevated plasma von Willebrand factor antigen (vWF) has been shown to indicate the presence of clinically significant portal hypertension, and thus, predicts the development of clinical events in patients with cirrhosis.
|
29377193 |
2018 |
|
Cirrhosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We analysed different parameters of VWF, including detailed multimer distribution by densitometry and platelet adhesion, together with <u>a</u><u>d</u>isintegrin-like <u>a</u>nd <u>m</u>etalloproteinase with <u>t</u>hrombo<u>s</u>pondin type-1 motifs <u>13</u> (ADAMTS13) activity and antigen and C-reactive protein (CRP) levels in patients with ST cirrhosis (<i>n</i> = 99), with AD (<i>n</i> = 54) and controls (<i>n</i> = 92).
|
29972862 |
2018 |
|
Cirrhosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results are the first to demonstrate that VWF deficiency reduces the progression of liver fibrosis, suggesting a mechanistic role of elevated plasma VWF levels in cirrhosis.
|
28527913 |
2017 |
|
Cirrhosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Patients with cirrhosis displayed higher serum levels of LPS (55.8 [42.2-79.9] vs. 23.0 [7.0-34.0]pg/ml, p<0.001), factor VIII (172.0 [130.0-278.0] vs. 39.0 [26.0-47.0]U/dl, p<0.0001), vWf (265.0 [185.0-366.0] vs. 57.0 [48.0-65.0]U/dl, p<0.001) and positivity for Escherichia coli DNA (88% vs. 3%, p<0.001, n=34) compared to controls.
|
28716745 |
2017 |
|
Cirrhosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In chronic hepatitis and cirrhosis, LYVE-1 expression in sinusoidal endothelium was attenuated, especially in areas adjacent to active inflammatory or fibrotic lesions, while von Willebrand factor was reciprocally expressed in sinusoidal endothelium.
|
19908110 |
2010 |
|
Cirrhosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The plasma concentration of both FVIII and VWF was significantly higher in patients with cirrhosis than control subjects (p = 0.038 and 0.010 respectively).
|
14961153 |
2004 |