WAS, WASP actin nucleation promoting factor, 7454

N. diseases: 204; N. variants: 37
Disease: T-Cell Lymphoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.020 Biomarker disease BEFREE Our findings demonstrate that WASP and WIP are tumor suppressors in T cell lymphoma and suggest that MAP-kinase kinase (MEK) inhibitors combined with ALK inhibitors could achieve a more potent therapeutic effect in ALK+ ALCL. 30510251 2019
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.020 Biomarker disease BEFREE We found that p53<sup>+/-</sup>WASp<sup>+</sup> mice developed malignancies, including solid tumors and T cell lymphomas with 71.4% of survival 24 weeks after irradiation. p53<sup>+/-</sup>WASp<sup>-</sup> mice showed lower survival rate and developed various early onset malignancies. 30393584 2018