WNT1, Wnt family member 1, 7471

N. diseases: 216; N. variants: 12
Disease: Cleft Palate ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0008925
Disease: Cleft Palate
Cleft Palate 		0.030 Biomarker disease BEFREE The Wnt1-Cre;Fam20bflox/flox mice died immediately after birth because of complete cleft palates. 30105814 2018
CUI: C0008925
Disease: Cleft Palate
Cleft Palate 		0.030 GeneticVariation disease BEFREE Tbx3 fl/fl; Wnt1-Cre conditional mutant mice die shortly after birth with cleft palate and difficulty feeding. 30292786 2018
CUI: C0008925
Disease: Cleft Palate
Cleft Palate 		0.030 GeneticVariation disease BEFREE Whereas deletion of Tak1 in the palatal epithelium or mesenchyme did not give rise to a cleft palate defect, inactivation of Tak1 in the neural crest lineage using the Wnt1-Cre transgenic allele resulted in failed palate elevation and subsequently the cleft palate formation. 23460641 2013