WNT3, Wnt family member 3, 7473

N. diseases: 140; N. variants: 22
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2931216
Disease: Tetra-amelia autosomal recessive
Tetra-amelia autosomal recessive 		0.620 Biomarker disease BEFREE Abnormalities of the Wnt3/3a pathway (located in the apical ectodermal ridge) include tetra-amelia and loss of the distal phalanges/nails. 20709709 2011
CUI: C2931216
Disease: Tetra-amelia autosomal recessive
Tetra-amelia autosomal recessive 		0.620 Biomarker disease GENOMICS_ENGLAND Tetra-amelia and lung hypo/aplasia syndrome: new case report and review. 18837045 2008
CUI: C2931216
Disease: Tetra-amelia autosomal recessive
Tetra-amelia autosomal recessive 		0.620 GeneticVariation disease BEFREE Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. 14872406 2004
CUI: C2931216
Disease: Tetra-amelia autosomal recessive
Tetra-amelia autosomal recessive 		0.620 Biomarker disease GENOMICS_ENGLAND Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. 14872406 2004
CUI: C2931216
Disease: Tetra-amelia autosomal recessive
Tetra-amelia autosomal recessive 		0.620 Biomarker disease HPO
CUI: C2931216
Disease: Tetra-amelia autosomal recessive
Tetra-amelia autosomal recessive 		0.620 Biomarker disease CTD_human
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.400 Biomarker disease CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.400 GeneticVariation disease GWASCAT Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
CUI: C0334634
Disease: Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 		0.310 AlteredExpression disease LHGDN Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. 18787224 2008
CUI: C0334634
Disease: Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 		0.310 Biomarker disease CTD_human Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. 18787224 2008
CUI: C0235480
Disease: Paroxysmal atrial fibrillation
Paroxysmal atrial fibrillation 		0.300 Biomarker disease CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
CUI: C2585653
Disease: Persistent atrial fibrillation
Persistent atrial fibrillation 		0.300 Biomarker phenotype CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
CUI: C3468561
Disease: familial atrial fibrillation
familial atrial fibrillation 		0.300 Biomarker phenotype CTD_human Biobank-driven genomic discovery yields new insight into atrial fibrillation biology. 30061737 2018
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma 		0.300 Biomarker disease CTD_human MicroRNA and mRNA features of malignant pleural mesothelioma and benign asbestos-related pleural effusion. 25756049 2015
CUI: C0751958
Disease: Lymphoma, Lymphocytic, Intermediate
Lymphoma, Lymphocytic, Intermediate 		0.300 Biomarker disease CTD_human Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. 18787224 2008
CUI: C2931218
Disease: Tetraamelia multiple malformations
Tetraamelia multiple malformations 		0.300 GermlineCausalMutation disease ORPHANET Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. 14872406 2004
CUI: C4012268
Disease: TETRAAMELIA SYNDROME, AUTOSOMAL RECESSIVE
TETRAAMELIA SYNDROME, AUTOSOMAL RECESSIVE 		0.300 Biomarker disease GENOMICS_ENGLAND Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. 14872406 2004
CUI: C4012268
Disease: TETRAAMELIA SYNDROME, AUTOSOMAL RECESSIVE
TETRAAMELIA SYNDROME, AUTOSOMAL RECESSIVE 		0.300 Biomarker disease GENOMICS_ENGLAND
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.120 Biomarker disease BEFREE Notably, the inhibition of Wnt3 partially reversed the promotion effect of SPAG5 on breast cancer cell proliferation and invasion and β-catenin/TCF4 signalling. 30854682 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.120 GeneticVariation disease GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.120 AlteredExpression disease BEFREE WNT3 was significantly up-regulated in a case of primary breast cancer and in a case of primary rectal cancer among various types of human primary cancers. 11604997 2001
CUI: C0021704
Disease: Intelligence
Intelligence 		0.100 GeneticVariation phenotype GWASCAT A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence. 29326435 2019
CUI: C0023114
Disease: Handedness
Handedness 		0.100 GeneticVariation phenotype GWASCAT Handedness, language areas and neuropsychiatric diseases: insights from brain imaging and genetics. 31504236 2019
CUI: C0016529
Disease: Forced expiratory volume function
Forced expiratory volume function 		0.100 GeneticVariation phenotype GWASCAT Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function. 30061609 2018
CUI: C0021704
Disease: Intelligence
Intelligence 		0.100 GeneticVariation phenotype GWASCAT Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. 29844566 2018