WNT10B, Wnt family member 10B, 7480

N. diseases: 90; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2749665
Disease: SPLIT-HAND/FOOT MALFORMATION 6 (disorder)
SPLIT-HAND/FOOT MALFORMATION 6 (disorder) 		0.700 CausalMutation disease CLINVAR Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. 25741868 2015
CUI: C2749665
Disease: SPLIT-HAND/FOOT MALFORMATION 6 (disorder)
SPLIT-HAND/FOOT MALFORMATION 6 (disorder) 		0.700 GeneticVariation disease CLINVAR Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. 25741868 2015
CUI: C2749665
Disease: SPLIT-HAND/FOOT MALFORMATION 6 (disorder)
SPLIT-HAND/FOOT MALFORMATION 6 (disorder) 		0.700 Biomarker disease GENOMICS_ENGLAND Novel homozygous mutations in the WNT10B gene underlying autosomal recessive split hand/foot malformation in three consanguineous families. 24211389 2014
CUI: C2749665
Disease: SPLIT-HAND/FOOT MALFORMATION 6 (disorder)
SPLIT-HAND/FOOT MALFORMATION 6 (disorder) 		0.700 GeneticVariation disease UNIPROT Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation. 18515319 2008
CUI: C2749665
Disease: SPLIT-HAND/FOOT MALFORMATION 6 (disorder)
SPLIT-HAND/FOOT MALFORMATION 6 (disorder) 		0.700 Biomarker disease GENOMICS_ENGLAND Evidence for autosomal recessive inheritance of split hand/split foot malformation: a report of nine cases. 12072797 2002
CUI: C2749665
Disease: SPLIT-HAND/FOOT MALFORMATION 6 (disorder)
SPLIT-HAND/FOOT MALFORMATION 6 (disorder) 		0.700 Biomarker disease CTD_human
CUI: C2749665
Disease: SPLIT-HAND/FOOT MALFORMATION 6 (disorder)
SPLIT-HAND/FOOT MALFORMATION 6 (disorder) 		0.700 Biomarker disease GENOMICS_ENGLAND
CUI: C4310730
Disease: TOOTH AGENESIS, SELECTIVE, 8
TOOTH AGENESIS, SELECTIVE, 8 		0.600 GeneticVariation disease UNIPROT Mutations in WNT10B Are Identified in Individuals with Oligodontia. 27321946 2016
CUI: C4310730
Disease: TOOTH AGENESIS, SELECTIVE, 8
TOOTH AGENESIS, SELECTIVE, 8 		0.600 Biomarker disease CTD_human
CUI: C4310730
Disease: TOOTH AGENESIS, SELECTIVE, 8
TOOTH AGENESIS, SELECTIVE, 8 		0.600 CausalMutation disease CLINVAR
CUI: C0020608
Disease: Hypodontia
Hypodontia 		0.420 GeneticVariation disease BEFREE They also show that WNT10B variants are associated not only with oligodontia and isolated tooth agenesis, but also with microdontia, short tooth roots, dental pulp stones, and taurodontism. 29364501 2018
CUI: C4082304
Disease: Oligodontia
Oligodontia 		0.420 GeneticVariation disease BEFREE They also show that WNT10B variants are associated not only with oligodontia and isolated tooth agenesis, but also with microdontia, short tooth roots, dental pulp stones, and taurodontism. 29364501 2018
CUI: C0020608
Disease: Hypodontia
Hypodontia 		0.420 GermlineCausalMutation disease ORPHANET Mutations in WNT10B Are Identified in Individuals with Oligodontia. 27321946 2016
CUI: C0020608
Disease: Hypodontia
Hypodontia 		0.420 GeneticVariation disease BEFREE Mutations in WNT10B Are Identified in Individuals with Oligodontia. 27321946 2016
CUI: C4082304
Disease: Oligodontia
Oligodontia 		0.420 GermlineCausalMutation disease ORPHANET Mutations in WNT10B Are Identified in Individuals with Oligodontia. 27321946 2016
CUI: C4082304
Disease: Oligodontia
Oligodontia 		0.420 GeneticVariation disease BEFREE Mutations in WNT10B Are Identified in Individuals with Oligodontia. 27321946 2016
CUI: C0020608
Disease: Hypodontia
Hypodontia 		0.420 Biomarker disease HPO
CUI: C4082304
Disease: Oligodontia
Oligodontia 		0.420 Biomarker disease HPO
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.350 Biomarker disease BEFREE Moreover, exosomes have a key role in paracrine Wnt10b transport from fibroblasts to breast cancer epithelial cells. 28394344 2017
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.350 Biomarker disease BEFREE Wnt10B was previously shown to be involved in breast cancer development. 28599424 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.350 Biomarker disease BEFREE Wnt10B was previously shown to be involved in breast cancer development. 28599424 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.350 Biomarker disease BEFREE Moreover, exosomes have a key role in paracrine Wnt10b transport from fibroblasts to breast cancer epithelial cells. 28394344 2017
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.350 Biomarker disease BEFREE Furthermore, our studies supports an autocrine activation primed by the formation of WNT10B-FZD4/5 complexes in the breast cancer MCF7 cells that express the WNT10B<sup>IVS1</sup>. 27853307 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.350 Biomarker disease BEFREE Furthermore, our studies supports an autocrine activation primed by the formation of WNT10B-FZD4/5 complexes in the breast cancer MCF7 cells that express the WNT10B<sup>IVS1</sup>. 27853307 2016
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.350 AlteredExpression disease BEFREE WNT10B mRNA was relatively highly expressed in TE3, TE6, TE10, TE11 (esophageal cancer), Hs700T (pancreatic cancer), SKG-IIIa, HeLa S3 (cervical cancer), and T-47D (breast cancer). 12239602 2002