WRN, WRN RecQ like helicase, 7486

N. diseases: 172; N. variants: 89
Disease: Premature aging syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 GeneticVariation disease BEFREE The induced pluripotent stem cell (iPSC) technology has provided a unique opportunity to develop disease-specific models and personalized treatment for genetic disorders, and is well suitable for the study of Werner syndrome (WS), an autosomal recessive disease with adult onset of premature aging caused by mutations in the RecQ like helicase (WRN) gene. 30206203 2018
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE WRNIP1 interacts with WRN helicase, which is defective in the premature aging disease Werner syndrome. 28118071 2017
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE Based on a screen of a number of chemicals, here we found that Vitamin C exerts most efficient rescue for many features in premature aging as shown in WRN-deficient MSCs, including cell growth arrest, increased reactive oxygen species levels, telomere attrition, excessive secretion of inflammatory factors, as well as disorganization of nuclear lamina and heterochromatin. 27271327 2016
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 GeneticVariation disease BEFREE Inactivating mutations in RECQL2 lead to Werner syndrome, a rare autosomal disease associated with premature aging and an increased susceptibility to multiple cancer types. 26690424 2015
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE Telomeric abnormalities caused by loss of function of the RecQ helicase WRN are linked to the multiple premature ageing phenotypes that characterize Werner syndrome. 26420422 2015
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 GeneticVariation disease BEFREE Werner syndrome (WS) is a premature aging disorder caused by WRN protein deficiency. 25931448 2015
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE Characterization of WRN separation-of-function mutants may provide insight to catalytic requirements for suppression of phenotypes associated with the premature aging disorder. 23276657 2015
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 GeneticVariation disease BEFREE As an analogy of the mechanism in natural aging, we described a hypothetical mechanism of premature aging in WS: telomere dysfunction induced by WRN mutation causes multiple premature aging phenotypes of WS, including shortened cellular lifespan and inflammation induced by ROS, such as diabetes mellitus. 24356923 2014
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE Although WS has been characterized by a variety of clinical manifestations mimicking premature aging, the recent longevity and delayed age-associated manifestations observed both from Japanese WS and general population may suggest a common environmental effect on some gene(s) other than WRN and may give us a newer pathophysiological look at WS and also natural aging through the molecular dysfunction of WRN. 23524889 2013
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE Mutations in the RecQ helicases BLM and WRN are linked to the cancer-prone disorder Bloom's syndrome and premature aging condition Werner syndrome, respectively. 23161009 2013
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE Werner syndrome (WS) is a disorder characterized by features of premature aging and increased cancer that is caused by loss of the RecQ helicase WRN. 22871734 2012
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 GeneticVariation disease BEFREE Mutations in WRN lead to genomic instability and the premature aging condition Werner syndrome. 22159421 2011
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 GeneticVariation disease BEFREE Mutation in the WRN protein leads to the premature aging disease Werner syndrome, a disorder that features neurodegeneration. 21550379 2011
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease CTD_human Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells. 21267443 2011
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 GeneticVariation disease BEFREE Werner syndrome is an autosomal recessive disease of premature aging caused by a polymorphic C1367T mutation in the Werner (WRN) gene. 20808731 2010
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 GeneticVariation disease BEFREE WRN-1 is the Caenorhabditis elegans homolog of the human Werner syndrome protein, a RecQ helicase, mutations of which are associated with premature aging and increased genome instability. 20062519 2010
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE Additionally high T-SCE rates have been observed in cells with deficiencies in WRN and BLM, the genes that are defective in Werner's and Bloom's syndromes, implying a connection to premature aging. 20952810 2010
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 GeneticVariation disease BEFREE Werner syndrome (WS) is an autosomal recessive disease characterized by premature aging and caused by mutations of the WRN gene mapped at 8p12. 19398855 2009
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 GeneticVariation disease BEFREE Mutations of the human RecQ helicase genes WRN and BLM lead to rare autosomal recessive disorders, Werner and Bloom syndromes, which are associated with premature aging and cancer predisposition, including breast cancer. 19205873 2009
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 GeneticVariation disease BEFREE BLM and WRN are also human RecQ helicases, which are mutated in Bloom and Werner's syndrome, respectively, and associated with chromosomal instability as well as premature aging. 19567405 2009
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3. 20157511 2009
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 GeneticVariation disease BEFREE Five members of the RecQ subfamily of DEx-H-containing DNA helicases have been identified in both human and mouse, and mutations in BLM, WRN, and RECQ4 are associated with human diseases of premature aging, cancer, and chromosomal instability. 18414032 2008
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 Biomarker disease BEFREE Future research should focus on the mechanism(s) of WRN in the regulation of the various DNA metabolism pathways and development of therapeutic approaches to treat premature aging syndromes such as WS. 17587522 2007
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 GeneticVariation disease BEFREE Mutations of the human RecQ helicase genes WRN and BLM lead to rare autosomal recessive disorders, Werner and Bloom syndromes, which are associated with premature ageing and cancer predisposition. 16501249 2006
CUI: C0231341
Disease: Premature aging syndrome
Premature aging syndrome 		0.400 GeneticVariation disease BEFREE Mutations in the WRN gene lead to the Werner syndrome (WS), which resembles premature aging. 16405962 2006