Myeloid Leukemia, Chronic
|
0.400 |
Biomarker
|
disease |
BEFREE |
The transcription factor ZNF224 plays a key proapoptotic role in chronic myelogenous leukemia (CML), by modulating Wilms Tumor protein 1 (WT1) dependent apoptotic genes transcription.
|
29423056 |
2018 |
Myeloid Leukemia, Chronic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Freshly diagnosed, imatinib-responsive, and -unresponsive patients among these revealed interesting changes in hTERT and WT1 gene expression profiles, especially in 25 patients with CML in whom sequential samples were analyzed.
|
21314483 |
2011 |
Myeloid Leukemia, Chronic
|
0.400 |
Biomarker
|
disease |
BEFREE |
The participants received cDNA from consecutive samples from a BCR-ABL+ chronic myeloid leukemia (CML) patient and an acute myeloid leukemia (AML) patient with both CBFβ-MYH11 and WT1 target genes, they conducted qPCR on their respective hardware platforms and generated a series of reports with pre-defined features.
|
21494256 |
2011 |
Myeloid Leukemia, Chronic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Graft-versus-leukemia effects of Wilms' tumor 1 protein-specific cytotoxic T lymphocytes in patients with chronic myeloid leukemia after allogeneic hematopoietic stem cell transplantation.
|
20497687 |
2010 |
Myeloid Leukemia, Chronic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to evaluate if the responsiveness of Chronic Myeloid Leukemia (CML) patients to Imatinib therapy was predictable from WT1 gene expression in peripheral blood leukocytes.
|
19580340 |
2009 |
Myeloid Leukemia, Chronic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Other attractive targets are the Wilms' tumor 1 antigen and the PR1 epitope from proteinase 3, a granule protein overexpressed in CML.
|
20425356 |
2007 |
Myeloid Leukemia, Chronic
|
0.400 |
Biomarker
|
disease |
CTD_human |
Chronic myeloid leukemia cells express tumor-associated antigens eliciting specific CD8+ T-cell responses and are lacking costimulatory molecules.
|
17157168 |
2006 |
Myeloid Leukemia, Chronic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Importantly, T cells stimulated with the new analogs crossreacted with the native WT1 peptide sequence and were able to kill HLA-matched chronic myeloid leukemia cell lines.
|
16990779 |
2006 |
Myeloid Leukemia, Chronic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The WT1 gene is considered to be highly expressed in patients with acute myeloid leukemia (AML), acute lymphoblastic leukemia and chronic myeloid leukemia and is thought to play a key role in maintaining the viability of leukemia cells.
|
15182334 |
2004 |
Myeloid Leukemia, Chronic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conclude that dominant-negative mutations of the zinc finger region of the WT1 gene are uncommon in CML blast crisis.
|
9222290 |
1997 |
Myeloid Leukemia, Chronic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Significant levels of WT1 gene were expressed in all leukemia patients and for CML the levels increased as the clinical phase progressed.
|
7949179 |
1994 |