WT1, WT1 transcription factor, 7490

N. diseases: 446; N. variants: 61
Disease: Urogenital Abnormalities ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0042063
Disease: Urogenital Abnormalities
Urogenital Abnormalities 		0.040 GeneticVariation group BEFREE The Wilms tumour (WT1) gene was first localized through its deletion in individuals with the WAGR syndrome (Wilms tumour, aniridia, genitourinary abnormalities and mental retardation). 7833922 1994
CUI: C0042063
Disease: Urogenital Abnormalities
Urogenital Abnormalities 		0.040 Biomarker group BEFREE In several cases, children had genitourinary abnormalities of the type associated with the WT1 gene on chromosome 11p13. 7954323 1994
CUI: C0042063
Disease: Urogenital Abnormalities
Urogenital Abnormalities 		0.040 GeneticVariation group BEFREE A point mutation found in the WT1 gene in a sporadic Wilms' tumor without genitourinary abnormalities is identical with the most frequent point mutation in Denys-Drash syndrome. 8381368 1993
CUI: C0042063
Disease: Urogenital Abnormalities
Urogenital Abnormalities 		0.040 GeneticVariation group BEFREE All four del(11)(p13) cases presented with WAGR, a complex syndrome associated with a predisposition to Wilms' tumor (WT), aniridia (A), genitourinary abnormalities (G), and mental retardation (R). 2570677 1989