Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Wilms' tumor 1 (WT1) is constantly expressed in leukemic cells of acute leukemia and myelodysplastic syndrome (MDS).
|
28860210 |
2017 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A high expression of Wilms tumor 1 (WT1) mRNA occurs in most cases of acute leukemia and myelodysplastic syndrome (MDS).
|
27866185 |
2017 |
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this regard, many studies have identified WT1 protein as a tumor antigen, considered a target molecule for clinical application in human acute leukemias.
|
27466479 |
2016 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study was assessment of WT1 gene expression in patients with acute leukemia, measurement of IL-12 and C3 levels in serum and evaluation of the relationship between them.
|
26514528 |
2015 |
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The Wilms' tumor (WT1) gene mutations were detected in patients with most forms of acute leukemia.
|
24074521 |
2014 |
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The role of the Wilms tumor 1 gene (WT1) in acute leukemias has been underscored by mutations found in acute myeloid leukemia identifying patients with inferior survival.
|
20435628 |
2010 |
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The clinical relevance of Wilms Tumour 1 (WT1) gene mutations in acute leukaemia.
|
20013787 |
2010 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
WT1 protein expression in childhood acute leukemia.
|
18161786 |
2008 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Positive immunostaining of WT1 was observed only in the portion of acute leukemia and overt leukemia (OL) transformed from MDS with a high WT1 message level, suggesting the relatively high detection threshold of WT1 protein with the immunostaining method.
|
17803653 |
2007 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The tumor suppressor gene wt1 (Wilms tumor 1) encodes a zinc finger transcription factor reported to be expressed in many tumors, including mesotheliomas, carcinomas, and acute leukemias.
|
15894924 |
2005 |
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The Wilms' tumor (WT1) gene is overexpressed in patients with most forms of acute leukemia.
|
15339675 |
2004 |
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
WT1 gene transcript assay for relapse in acute leukemia after transplantation.
|
15223632 |
2004 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Prognostic significance of quantitative analysis of WT1 gene transcripts by competitive reverse transcription polymerase chain reaction in acute leukaemia.
|
14510942 |
2003 |
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of WT1 gene function has been implicated in the development of malignancies including Wilms' tumor and acute leukemias.
|
10706085 |
2000 |
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The nuclear WT1 protein can be found in blasts of approximately 50-60% of acute leukemia patients at diagnosis.
|
10674900 |
2000 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recent observations in adult patients with acute leukaemia suggest that wt1 gene expression is a poor prognostic factor.
|
10480287 |
1999 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recently, we and others found Wilms' tumour (WT1) gene expression to be increased in virtually all patients with acute leukaemias, whereas normal haemopoietic progenitors express the WT1 gene at much lower levels or not at all.
|
9609529 |
1998 |
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using semiquantitative RT-PCR, we investigated the expression of the WT-1 gene in peripheral bloods (PBs) of 33 patients with acute leukemia (AML 26; ALL 7) and monitored its expression after achievement of CR.
|
9339129 |
1997 |
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Clear correlation was observed between the relative levels of WT1 gene expression (< 0.6 v > or = 0.6) and the prognosis for acute leukemia (AML, ALL, and AMLL).
|
7949179 |
1994 |