WT1, WT1 transcription factor, 7490

N. diseases: 446; N. variants: 61
Disease: Carcinoma of lung ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.030 Biomarker disease BEFREE Subsequent research has shown that the WT1 gene in many other cases acts as an oncogene, most prominently in leukaemia and lung cancer (even though these cancer forms can emerge as a result of many other aetiological factors). 25189877 2015
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.030 PosttranslationalModification disease BEFREE Changes in the pattern of methylation of the WT1 gene have not yet been studied in detail in human lung cancer. 22925896 2012
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.030 Biomarker disease BEFREE These results suggest that the nonmutated, wild-type WT1 gene plays an important role in tumorigenesis of de novo lung cancers and may provide us with the rationale for new therapeutic strategies for lung cancer targeting the WT1 gene and its products. 12115544 2002