|
Malignant neoplasm of breast
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The analysis revealed already well-established associations with XBP1 and FOXA1, but also identified a strong association with CT62, a potential immunotherapeutic target with few previous associations with breast cancer.
|
30760519 |
2019 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We present data on the alternative and novel roles played by SMAD3, CREB-pSer133 and particularly XBP1 in oestrogen signalling in endometrial and breast cancer.
|
30121621 |
2019 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
XBP1 is a key regulator of Rab9 and further confirmed that Rab9 play important roles in breast cancer tumorigenesis.
|
30881034 |
2019 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Total XBP1 (F(1/126) = 9.550, p = 0.002, Partial η<sup>2</sup> = 0.070) and unspliced XBP1 (F(1/128)= 8.803, p= 0.004, Patial η<sup>2</sup> = 0.065) were significantly decreased in BD.
|
29843019 |
2018 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We conclude that <i>NAT1</i> expression is not directly regulated by E<sub>2</sub>, DHT, 3<i>β</i>-adiol, or dithiothreitol despite high <i>NAT1</i> and <i>ESR1</i> expression in luminal A breast cancer cells, suggesting that <i>ESR1</i>, <i>XBP1,</i> and <i>NAT1</i> expression may share a common transcriptional network arising from the luminal epithelium associated with better survival in breast cancer.
|
29339455 |
2018 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to fine tune the HIF1α/VEGFA axis in breast cancer angiogenesis.
|
29367761 |
2018 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we show that oncogenic MYC regulates the inositol-requiring enzyme 1 (IRE1)/X-box binding protein 1 (XBP1) branch of the UPR in breast cancer via multiple mechanisms.
|
29480818 |
2018 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, independently of other clinicopathological factors, the nuclear expression of XBP1s is correlated with shorter breast cancer survival; however, whether nuclear XBP1s is an independent prognostic biomarker needs to be confirmed by further studies with larger samples and detailed sample stratification.
|
29276395 |
2017 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
Accumulating evidences suggest that signal transduction in human breast cancers commences in estrogen-reliant pattern via signaling of the estrogen-receptor α-subunit (ERα) and XBP-1 (bZIP-domain) proteins.
|
28111258 |
2017 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Activation of XBP1 has been implicated in various human tumors including breast cancer.
|
28707320 |
2017 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of NCOA3 was associated with poor prognosis and higher levels of XBP1-S in breast cancer tissues.
|
27109102 |
2016 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We next investigate the expression of XBP1s in over 170 breast cancer patients' samples and the results demonstrate that XBP1s expression level is highly correlated with overall survival in the ER+ subgroup, but not in the ER- subgroup, suggesting a potential therapeutic application of XBP1 inhibitors in ER+breast cancer treatment.
|
26517687 |
2015 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings provide new insights into the fundamental signaling activities of spliced and unspliced XBP1 in breast cancer, establish NF-κB to be a mediator of these activities, and identify XBP1 and its splicing to be novel therapeutic targets.
|
25368386 |
2015 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
High XBP1 protein also predicts shorter overall survival of breast cancer patients.
|
25280941 |
2015 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The XBP1-116C/G polymorphism is associated with an increased risk of bipolar disorder in Asian population.
|
25231123 |
2014 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The XBP1-116C/G polymorphism is associated with an increased risk of bipolar disorder in Asian population.
|
25231123 |
2014 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here we report that XBP1 is activated in TNBC and has a pivotal role in the tumorigenicity and progression of this human breast cancer subtype.
|
24670641 |
2014 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The origin of coordinate expression of ESR1 and XBP1 observed in whole tissue sections of human breast cancer biopsies is due principally to their co-expression in carcinoma cells and not in the surrounding stromal cells as substantiated using LCM-procured cells.
|
21858728 |
2011 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
X-box binding protein-1 is also an estrogen-dependent gene and is associated with better survival for breast cancer patients.
|
20208137 |
2010 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Induction of the spliced form of XBP1 as well as total XBP1 by thapsigargin was significantly attenuated in patients with BD.
|
18771604 |
2009 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A functional polymorphism (-116C-->G) in the XBP1 promoter was linked in some studies to bipolar disorder.
|
19154631 |
2009 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Preliminary evidence on the association between XBP1-116C/G polymorphism and response to prophylactic treatment with valproate in bipolar disorders.
|
19564049 |
2009 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Induction of the spliced form of XBP1 as well as total XBP1 by thapsigargin was significantly attenuated in patients with BD.
|
18771604 |
2009 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of GRP78 and XBP-1 was demonstrated in 76% and 90% of the breast cancers, respectively, and correlated with oestrogen receptor positivity (P=0.045 and 0.017, respectively).
|
19861963 |
2009 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We therefore evaluated XBP-1 mRNA splicing as a factor in response of breast cancer patients to endocrine treatment.
|
18386815 |
2008 |