XBP1, X-box binding protein 1, 7494

N. diseases: 234; N. variants: 6
Disease: Cystic Fibrosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.040 Biomarker disease BEFREE Moreover, the IRE1α-XBP1 pathway of the UPR is responsible for the hyper-metabolic state seen in CF macrophages, which is associated with the exaggerated inflammatory response. 31428093 2019
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.040 Biomarker disease BEFREE This review discusses the contribution of airway epithelia and airway macrophages to CF airway inflammatory responses and specifically highlights the functional importance of the UPR pathway mediated by IRE1/XBP-1 in these processes. 28075361 2017
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.040 Biomarker disease BEFREE To evaluate inflammatory responses of AMs from chronically infected/inflamed human CF lungs and test whether XBP-1s is required for AM-mediated inflammation. 26331676 2015
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.040 Biomarker disease BEFREE XBP-1s was increased in freshly isolated infected/inflamed CF in comparison with normal HBE. 19321437 2009