XIST, X inactive specific transcript, 7503

N. diseases: 146; N. variants: 0
Disease: Degenerative polyarthritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.040 Biomarker disease BEFREE XIST knockdown could improve the inflammatory microenvironment in OA via acting on M1 macrophages, subsequently affecting the apoptosis of cocultured chondrocytes. miR-376c-5p inhibition exerts an opposing effect on M1 macrophages and cocultured chondrocytes, as well as significantly reverses the effect of XIST knockdown. 31215024 2020
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.040 Biomarker disease BEFREE In conclusion, the present study suggests that XIST promotes MMP‑13 and ADAMTS5 expression, indicating ECM degradation, by functioning as a ceRNA of miR‑1277‑5p in OA. 31198977 2019
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.040 AlteredExpression disease BEFREE In addition, cartilage tissues of OA showed upregulation of lncRNA XIST and downregulation of TIMP-3. 31815654 2019
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.040 Biomarker disease BEFREE Thus, lncRNA XIST might be considered as a potential therapeutic target for OA treatment. 30005876 2018