XIST, X inactive specific transcript, 7503

N. diseases: 146; N. variants: 0
Disease: Pancreatic carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.050 Biomarker disease BEFREE Long non-coding RNA XIST regulates the EGF receptor to promote TGF-β1-induced epithelial-mesenchymal transition in pancreatic cancer. 31013436 2019
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.050 AlteredExpression disease BEFREE We detected the XIST expression in PC tissues and cells by qRT-PCR. 31213574 2019
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.050 Biomarker disease BEFREE Knockdown of XIST in two PC cell lines caused inhibition of migration, invasion and EMT capacities. 31163263 2019
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.050 AlteredExpression disease BEFREE Taken together, our data indicated that XIST might be an oncogenic lncRNA that promoted proliferation of PC cell line through inhibiting miR-140/miR-124 expression and promoting cell cycle-related factor expression, and could be regarded as a therapeutic target in human pancreatic carcinoma. 29371940 2017
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.050 Biomarker disease BEFREE In our research, lncRNA-XIST was specifically upregulated in PC tissues and cell lines, and high XIST expression in PC was related to poorer prognosis (larger tumor size, perineural invasion, lymph node micrometastases, and shorter overall survival).XIST augmented PC cell proliferation. 28295543 2017