|
Alzheimer's Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
Frameshift (+1) proteins such as APP(+1) and UBB(+1) accumulate in sporadic cases of Alzheimer disease (AD) and in older subjects with Down syndrome (DS).
|
16432153 |
2006 |
|
Alzheimer's Disease
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these data show that co-expression of APP695 and APP(+1) affects the processing of APP695 in a pro-amyloidogenic way and this could gradually contribute to Alzheimer's disease pathology, as has been implicated in Down's syndrome patients.
|
15255950 |
2004 |
|
Alzheimer's Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
Moreover, beta APP+1 and UBB+1 proteins accumulate in the neuropathological hallmarks of AD.
|
10911966 |
2000 |
|
Alzheimer's Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
The occurrence of +1 frameshifted proteins, such as amyloid precursor protein (APP+1) and ubiquitin-B (UBB+1) in Down syndrome (DS) has been linked to the onset of Alzheimer's disease (AD).
|
10666673 |
1999 |
|
Adenomatous Polyposis Coli
|
0.030 |
Biomarker
|
disease |
BEFREE |
One set of motifs frequently lost in these cancer-associated truncations is the SAMP repeats that mediate interactions between APC and Axin.
|
26446838 |
2015 |
|
Adenomatous Polyposis Coli
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our data showed that a short domain containing the first SAMP repeat in truncated APC was required to stimulate Axin oligomerisation.
|
24722208 |
2014 |
|
Down Syndrome
|
0.030 |
Biomarker
|
disease |
BEFREE |
APP(+1) is present in many neurons and beaded neurites in very young cases of DS, which suggests that it is axonally transported.
|
16432153 |
2006 |
|
Complete Trisomy 21 Syndrome
|
0.030 |
Biomarker
|
disease |
BEFREE |
APP(+1) is present in many neurons and beaded neurites in very young cases of DS, which suggests that it is axonally transported.
|
16432153 |
2006 |
|
Down Syndrome
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these data show that co-expression of APP695 and APP(+1) affects the processing of APP695 in a pro-amyloidogenic way and this could gradually contribute to Alzheimer's disease pathology, as has been implicated in Down's syndrome patients.
|
15255950 |
2004 |
|
Complete Trisomy 21 Syndrome
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these data show that co-expression of APP695 and APP(+1) affects the processing of APP695 in a pro-amyloidogenic way and this could gradually contribute to Alzheimer's disease pathology, as has been implicated in Down's syndrome patients.
|
15255950 |
2004 |
|
Down Syndrome
|
0.030 |
Biomarker
|
disease |
BEFREE |
The occurrence of +1 frameshifted proteins, such as amyloid precursor protein (APP+1) and ubiquitin-B (UBB+1) in Down syndrome (DS) has been linked to the onset of Alzheimer's disease (AD).
|
10666673 |
1999 |
|
Adenomatous Polyposis Coli
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Mammalian APC2, which closely resembles APC in overall domain structure, was functionally analyzed and shown to contain two SAMP domains, both of which are required for binding to conductin.
|
10021369 |
1999 |
|
Complete Trisomy 21 Syndrome
|
0.030 |
Biomarker
|
disease |
BEFREE |
The occurrence of +1 frameshifted proteins, such as amyloid precursor protein (APP+1) and ubiquitin-B (UBB+1) in Down syndrome (DS) has been linked to the onset of Alzheimer's disease (AD).
|
10666673 |
1999 |
|
Colitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Furthermore, preemptive dexamethasone treatment of DSS-challenged SAMP mice led to changes in flora composition without preventing the development of colitis.
|
31843928 |
2019 |
|
Crohn Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
In the present study, we show that neutralization of IL-1α by a specific monoclonal antibody against murine IL-1α was highly effective in reducing inflammation and damage in SAMP mice, mice that spontaneously develop a Crohn's-like ileitis.
|
31843928 |
2019 |
|
Colitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Epicutaneous tolerance to a model antigen prevented intestinal inflammation in the dextran sodium sulfate and SAMP-YITFc models and importantly could halt disease in mice already experiencing weight loss in the T-cell transfer model of colitis.
|
29019858 |
2017 |
|
Crohn Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
We have identified Pparg as a susceptibility gene in both the SAMP/Yit mouse and in human Crohn's disease.
|
15685547 |
2005 |
|
Cognition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
DHA Selectively Protects SAMP-8-Associated Cognitive Deficits Through Inhibition of JNK.
|
29911253 |
2019 |
|
Impaired cognition
|
0.010 |
Biomarker
|
disease |
BEFREE |
DHA Selectively Protects SAMP-8-Associated Cognitive Deficits Through Inhibition of JNK.
|
29911253 |
2019 |
|
Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Finally, on PET imaging study using [<sup>18</sup>F]APP-1 with tumor-bearing mice, the H3255 tumor (L858R mutant) was more clearly visualized than the H1975 tumor (L858R/T790M mutant).
|
28435529 |
2017 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Of particular note were opposing alterations of Xaa-Pro Aminopeptidases-1 and -2 (XPNPEP-1 and -2): a strong decrease of XPNPEP-2 in ccRCC was accompanied by abundant presence of the related protease XPNPEP-1.
|
29245961 |
2017 |
|
Cerebrovascular accident
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Of 126 spontaneously hypertensive stroke-prone rat genes, 10 were nominally associated with WMH volume or score in subjects from LBC1936, of which 5 (AFP, ALB, GNAI1, RBM8a, and MRPL18) were associated with both WMH volume and score (P<0.05); 2 of the 10 (XPNPEP1, P=6.7×10(-5); FARP1, P=0.024) plus another spontaneously hypertensive stroke-prone rat gene (USMG5, P=0.00014), on chromosomes 10, 13, and 10 respectively, were associated with WMH in subjects from CHARGE.
|
25586835 |
2015 |
|
Biliary Atresia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, expression data suggest that ADD3, but not XPNPEP1, is differentially expressed in BA patients.
|
24104524 |
2014 |
|
Congenital atresia of extrahepatic bile duct
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, expression data suggest that ADD3, but not XPNPEP1, is differentially expressed in BA patients.
|
24104524 |
2014 |
|
Coughing
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In addition, genetic interactions between peptidases involved in kinins levels (CPN1 and XPNPEP1) and proteins related to prostaglandin metabolism (PTGIS and PTGIR) strongly modify the risk of ACEi-induced cough presentation (0.102≤OR≤0.384 for protective combinations and 2.732≤OR≤7.216 for risk combinations).
|
21052031 |
2011 |