XRCC1, X-ray repair cross complementing 1, 7515

N. diseases: 410; N. variants: 39
Disease: Malignant tumor of colon ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.040 GeneticVariation disease BEFREE The present meta-analysis suggests that the XRCC1 Arg194Trp polymorphism may modify the risk for CRC, particularly colon cancer. 23857281 2013
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.040 Biomarker disease BEFREE Polymorphisms in MTHFR, XRCC1 and TS are related to toxicities and disease-free survival in patients with colon cancer. 23314736 2013
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.040 GeneticVariation disease BEFREE The 148Asp APE1 allele and the 399Gln XRCC1 allele apparently increased the risk of colon cancer (OR = 1.9-2.3 and OR = 1.5-2.1, respectively). 20720310 2010
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.040 GeneticVariation disease BEFREE In a study of 1,604 incident colon cancer cases and 1,969 matched population-based controls genotyped for BER variants OGG1 (S326C) and XRCC1 (R194W, R280H, and R399Q), we found no associations with colon cancer overall. 19959686 2009