Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There was also no association observed between XRCC1 haplotypes and CRC (P>0.05).
|
28059856 |
2017 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
While, single nucleotide polymorphisms (SNP) of ERCC1 and XRCC1 have be proved to influence clinical outcome of colorectal cancer patients treated with oxaliplatin-based chemotherapy.
|
29153096 |
2017 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, this study was aimed to examine whether XRCC1 plays a role in the 5-FU/AMPK agonist (AICAR)-induced cytotoxic effect on CRC and the underlying mechanisms.
|
29117108 |
2017 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, reducing the levels of miR-17-5p/miR-106b-5p, we increased the chemo-sensitivity of RCC/CRC-derived cells to anti-tumour drugs used in the clinic.
|
28327152 |
2017 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The genetic variant in the XRCC1 may not be associated with the survival of CRC patients in Thailand.
|
27221895 |
2016 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that inheritance of variant alleles in XRCC1 Arg194Trp and Arg399Gln SNPs may act as biomarkers for the early detection of GIC, especially for gastric and colorectal cancers in the Sabah population.
|
27221877 |
2016 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Related databases of Medline, CNKI, and Wanfang were systematic searched for the studies related to XRCC1 rs1799782 C>T polymorphisms and colorectal cancer risk in Chinese Han population.
|
28230032 |
2016 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, we showed that the carriers of allele A in XRCC1 (rs25487, G > A) were connected with a higher risk of disseminated CRC (Odds Ratio = 1.64; 95% Confidence Interval = 1.12-2.41, p = 0.012).
|
27328741 |
2016 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Taking smoking and drinking habits into consideration, we found that subjects with heavy smoking history and XRCC1 194Arg allele had the significantly increased risk for CRC (OR=2.91, 95% CI 1.35-6.24).
|
26271249 |
2015 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Results showed that Trp/Trp genotype of XRCC1 Arg194Trp and AA genotype of ERCC1 rs2336219 have a significantly increased risk of CRC; Trp allele of XRCC1 Arg194Trp and CC genotype of ERCC1 rs735482 were associated with lower response to oxaliplatin-based chemotherapy, a shorter survival and a higher risk of relapse or metastasis.
|
25690281 |
2015 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis confirms the association between XRCC1 Arg399Gln polymorphism and CRC risk and suggests that the heterogeneity is not strongly modified by ethnicity and deviation from the Hardy-Weinberg equilibrium.
|
25921133 |
2015 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest an increased risk for CRC in individuals with XRCC1 Arg194Trp polymorphism suggesting BER repair pathway modulates the risk of developing colorectal cancer in the Kashmiri population.
|
26434847 |
2015 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
After excluding two studies that deviated from the Hardy-Weinberg equilibrium, there remained no significant association between XRCC1 R399Q and CRC risk.
|
25582318 |
2015 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the univariate analysis, factors found to be significantly associated with an increased risk for CRC were the presence of the XRCC1 AA homozygote (OR= 4.95; 95% CI: 1.99-12.3), a first degree family history of cancer (OR= 1.74; 95% CI: 1.18-2.58), and a high frequency of pork consumption (OR= 1.49; 95% CI: 1.00-2.21).
|
25227862 |
2014 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
When combined effects of XRCC1 polymorphisms and alcohol consumption were analyzed, we found that the 194Trp or 399Gln alleles further increased the colorectal cancer risk due to high alcohol intake.
|
24377576 |
2014 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There were no associations between OGG1, XRCC1, or APE1 promoter polymorphisms and CRC risk.
|
25024628 |
2014 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
X-ray repair cross-complementing 1 polymorphism and prognosis of platinum-based chemotherapy in gastric and colorectal cancer: a meta-analysis.
|
24224851 |
2014 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
PARP1 762 recessive model (OR = 1.57, 95 % CI 1.12-2.20) and XRCC1 194 dominant model (OR = 1.45, 95 % CI 1.12-1.88) were associated with increased CRC risk.
|
23430444 |
2013 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, the decrease efficiency of DNA repair were correlated with the 399Gln/Gln XRCC1 and the 324His/His MUTYH genotypes occurrence in CRC patients.
|
23618615 |
2013 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The XPD and XRCC1 allelic variants may be prognostic markers for CRC patients receiving 5-FU based chemotherapy.
|
23894404 |
2013 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis provides an evidence for the association between XRCC1 Arg399Gln polymorphism and colorectal cancer risk in Chinese population, and XRCC1 Arg399Gln variant genotypes contribute to increased risk of colorectal cancer in Chinese.
|
23712778 |
2013 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The XRCC1 heterozygote status appears to be a strong risk factor for CRC development in the Kashmiri population.
|
24377605 |
2013 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present meta-analysis suggests that the XRCC1 Arg194Trp polymorphism may modify the risk for CRC, particularly colon cancer.
|
23857281 |
2013 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The statistically significant association between the XRCC1 Arg399Gln polymorphism and CRC risk was observed among studies with high quality and in Asians, but not in Caucasians.
|
23188703 |
2013 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association between XRCC1 and XRCC3 polymorphisms and colorectal cancer risk: a meta-analysis of 23 case-control studies.
|
23271134 |
2013 |