Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Moreover, in the subgroup analysis by cancer type, we found that XRCC1-rs25489 polymorphism was associated with an increased risk of bladder cancer (BC) in heterozygote model.
|
28330811 |
2017 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
APEX1 rs3136817, MUTYH rs3219493, three SNPs (rs3213356, rs25487 and rs1799782) in XRCC1, and three SNPs (rs1799794, rs861531 and rs861530) in XRCC3 showed significant associations with the risk of bladder cancer.
|
27153553 |
2016 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to examine the association between polymorphisms of DNA repair genes, namely X-ray repair cross-complementing group I (XRCC1) rs2854509 and rs3213255, and bladder cancer recurrence risk.
|
25616696 |
2015 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The analysis suggests that the XRCC1 Arg399Gln polymorphism might be a moderate risk factor for bladder cancer, especially in non-Asian population.
|
24176953 |
2014 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We identified no association between the XRCC1 Arg399Gln polymorphism and bladder cancer risk.
|
25501209 |
2014 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DNA adducts were instead positively associated with occupational cumulative exposure to AAs (p = 0.028), whereas XRCC1 Arg 399 (p<0.006) was related with a decreased adduct levels, but with no impact on BC risk.
|
24722645 |
2014 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polymorphism of DNA repair genes OGG1, XRCC1, XPD and ERCC6 in bladder cancer in Belarus.
|
25089939 |
2014 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This is the first meta-analysis conducted in Asian investigating the correlation between XRCC1 polymorphisms and susceptibility to bladder cancer.
|
23704969 |
2013 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the XRCC1 gene modify survival of bladder cancer patients treated with chemotherapy.
|
23553206 |
2013 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variants in the XRCC1 gene might alter protein structure or function or create alternatively spliced proteins which may influence BER efficiency and hence affect individual susceptibility to bladder cancer.
|
24039945 |
2013 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis results suggest that XRCC1 Arg194Trp and Arg280His polymorphisms are associated with significantly increased risk of bladder cancer in Asians.
|
23636799 |
2013 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Crude odds ratios with 95% confidence intervals were used to assess the associations between XRCC1 Arg194Trp and Arg399Gln polymorphisms and bladder cancer risk.
|
23496911 |
2013 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the results of the present study suggest that XRCC1 Arg399Gln polymorphism might not modify the susceptibility to bladder cancer.
|
23479765 |
2013 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggested that XRCC1 Arg194Trp and Arg280His polymorphisms were risk factors for increasing bladder cancer in Asian population.
|
24266849 |
2013 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotype of XRCC1 also associated with significant risk for PCa and BC.
|
22019847 |
2012 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined the associations between bladder cancer and 7 polymorphisms from 5 genes involved in the maintenance of genetic stability (MMR: MLH1-93G>A; BER: XRCC1--77T>C and Arg399Gln; NER:XPC Lys939Gln and PAT +/-; DSBR:ATM G5557A and XRCC7 G6721T) in 302 incident bladder cancer cases and 311 hospital controls.
|
22927776 |
2012 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that the XRCC1 and APE1 polymorphisms may contribute to susceptibility to bladder cancer.
|
20218899 |
2010 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No association was found between bladder cancer risk and the XRCC1 399 polymorphism. p53 mutations were found in 20.1% (35/174) patients.
|
20514470 |
2010 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No association was found between the polymorphisms in XRCC1 (Arg(194)Trp, Arg(280)His, Arg(399)Gln) and bladder cancer susceptibility.
|
18336890 |
2008 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genotyping for three polymorphic sites of XRCC1 gene at codon Arg194Trp (PvuII), Arg280His (RsaI) and Arg399Gln (MspI) in 140 BC cases and 190 controls by PCR-RFLP method was done.
|
18364571 |
2008 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we recruited 251 bladder cancer cases and 251 healthy controls to evaluate the effect of hOGG1 codon 326 and XRCC1 codon 399 polymorphisms on bladder cancer.
|
18272472 |
2008 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further studies based on larger, stratified population were required to explore the role of XRCC1 polymorphisms in bladder cancer risk.
|
18765423 |
2008 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found no evidence of an association between any of the 14 XRCC1 polymorphisms and bladder cancer risk.
|
17425776 |
2007 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, in the case of XRCC1, there was no significant difference in susceptibility to bladder cancer development between patients with the Arg399 and these with the Gln399 allele (OR.0.72 (95% CI, 0.41-1.26)).
|
17214369 |
2007 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In order to examine the association of common genetic variation in the base-excision repair (BER) pathway with bladder cancer risk, we analyzed 43 single nucleotide polymorphisms (SNPs) in 12 BER genes (OGG1, MUTYH, APEX1, PARP1, PARP3, PARP4, XRCC1, POLB, POLD1, PCNA, LIG1, and LIG3).
|
17203305 |
2007 |