XRCC4, X-ray repair cross complementing 4, 7518

N. diseases: 192; N. variants: 29
Disease: Lymphoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.120 GeneticVariation group BEFREE We now show that CD21-cre-mediated deletion of the Xrcc4 NHEJ gene in p53-deficient peripheral B cells leads to recurrent surface Ig-negative B lymphomas ("CXP lymphomas"). 19064702 2008
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.120 Biomarker group BEFREE Mice doubly deficient for either XRCC4 or DNA ligase IV and p53 invariably develop lymphomas bearing characteristic chromosome translocations with gene amplification. 12150897 2002
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.120 Biomarker group HPO