|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
T-cell receptor gamma and delta gene rearrangements and junctional region characteristics in south Indian patients with T-cell acute lymphoblastic leukemia.
|
17133429 |
2007 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clonal T-cell receptor gamma and delta gene rearrangements in T-cell acute lymphoblastic leukemia at diagnosis: predictor of prognosis and response to chemotherapy.
|
15061208 |
2004 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
T-cell receptor gamma and delta gene rearrangements in T-cell acute lymphoblastic leukemia in Indian patients.
|
10674905 |
2000 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The described T-ALL and the T cell line can serve as an experimental model in further studies on the regulatory elements involved in the specific deletion of the TCR-delta gene complex.
|
9379030 |
1997 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The previously observed preferential occurrence of tal-1 deletion type 1 in TcR-alpha beta + vs CD3- T-ALL and in T-ALL with both vs one TcR-delta genes deleted, disappeared when we retricted to T-ALL with completely demethylated taldb1.
|
8208530 |
1994 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The t(10;14) chromosomal translocation of T-cell acute lymphoblastic leukemia joins the T-cell receptor delta gene to a region upstream of a diverged homeobox-containing gene called HOX11.
|
7905617 |
1994 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, we conclude that alpha/beta lineage commitment of the T-ALL and especially the extent of TCR-delta gene deletions determines the chance of a tal-1 deletion.
|
8459224 |
1993 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Application of these probes for detailed analysis of the TCR-delta genes in normal control samples, 138 T-cell acute lymphoblastic leukemias (T-ALL), and 91 precursor B-ALL allowed us to determine the TCR-delta gene restriction map for five restriction enzymes, as well as the Southern blot restriction enzyme patterns of all theoretically possible TCR-delta gene rearrangements.
|
8219197 |
1993 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The combinatorial repertoire of the TcR-delta genes was homogeneous, as in all ten T-ALL at least one allele contained a V delta 1-J delta 1 rearrangement.
|
1826936 |
1991 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The analysis of the TCR beta, -gamma, and -delta gene configurations in 23 of the 40 T-ALLs showed that: (1) the lack of TCR protein expression was due to the lack of TCR gene rearrangements only in one of nine cases; (2) five of five TCR beta+, TCR alpha- cases studied had germline TCR alpha genes (ie, no detectable TCR delta gene deletions); (3) seven of eight cases with TCR delta gene deletions expressed TCR alpha proteins, whereas in 12 of 20 of the T-ALLs with TCR beta gene rearrangements the synthesis of the corresponding protein occurred; only 2 of 16 cases with rearranged TCR delta genes expressed TCR delta chains.
|
1826223 |
1991 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We analyzed the usage of the delta recombining element (delta Rec) and six V delta genes in cell samples from 15 patients with CD3- and 10 patients with CD3+ T-cell acute lymphoblastic leukemia in an attempt to define the hierarchy of genetic events that is associated with the T-cell receptor (TCR) alpha/delta gene complex during T-cell ontogeny.
|
1655121 |
1991 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The combinatorial repertoire of the expressed TcR-delta genes was homogeneous, as all thirteen T-ALL expressed V delta 1-D delta-J delta 1-C delta protein chains.
|
1837811 |
1991 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Acute T-lymphocytic leukemia with Ph1 and 5q-chromosome abnormalities and rearrangements of bcr and TCR-delta genes.
|
2147972 |
1990 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rearrangement of T cell receptor beta, gamma, and delta gene loci in human pre-T cell acute lymphoblastic leukemia.
|
2542699 |
1989 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Remarkably, one of these T-ALLs also contained TcR-alpha transcripts in addition to the immature TcR-delta transcripts, which was in line with the deletion of one TcR-delta gene allele and rearrangement of the other allele.
|
2526664 |
1989 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
T cell receptor delta gene recombinatorial events were found in 91% of acute T cell lymphoblastic leukemia, 68% of non-T, non-B lymphoid precursor acute lymphoblastic leukemia (ALL) and 80% of mixed lineage acute leukemias.
|
2547833 |
1989 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rearrangements of the T cell receptor delta gene in T acute lymphoblastic leukemia cells are distinct from those occurring in B lineage acute lymphoblastic leukemia and preferentially involve one V delta gene segment.
|
2523429 |
1989 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transcription of the TCR-delta gene was also analyzed in six T-ALL.
|
2848865 |
1988 |