ZIC3, Zic family member 3, 7547

N. diseases: 93; N. variants: 19
Disease: Neural Tube Defects ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027794
Disease: Neural Tube Defects
Neural Tube Defects 		0.030 Biomarker group BEFREE Zic3 null mice recapitulate the human heterotaxy phenotype but also have early gastrulation defects, axial patterning defects and neural tube defects complicating an assessment of the role of Zic3 in cardiac development. 23303524 2013
CUI: C0027794
Disease: Neural Tube Defects
Neural Tube Defects 		0.030 Biomarker group BEFREE Our data indicate that ZIC1, ZIC2, and ZIC3 are not major risk factors for NTD in humans. 14679585 2004
CUI: C0027794
Disease: Neural Tube Defects
Neural Tube Defects 		0.030 GeneticVariation group BEFREE These patients occasionally also show spina bifida, indicating that genetic variation in human ZIC3 may contribute to other congenital malformations, including neural tube defects. 10861288 2000