|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor ploidy and expression of renal differentiation antigens as recognized by a previously described series of monoclonal antibodies (MAbs) (RC2, RC3, RC4, RC38, RC69, RC154 and G250) were assessed in 48 renal-cell carcinomas.
|
3182107 |
1988 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To determine whether G250 antigen (MN/CA IX/G250) could be a potential therapeutic target and a tumour marker, a total of 147 cases of RCC were investigated immunohistochemically as well as by reverse transcriptase polymerase chain reaction (RT-PCR) analysis.
|
10574265 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Generalized up-regulation of CA IX in VHL-associated renal cell carcinoma contrasted with focal perinecrotic expression in a variety of non-VHL-associated tumors.
|
11156414 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We conclude that the cell surface trans-membrane carbonic anhydrases CA IX and CA XII are overexpressed in many tumors suggesting that this is a common feature of cancer cells that may be required for tumor progression.
|
11238039 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings may have important implications for the use of GM-CSF-G250 FP as a tumor vaccine for the treatment of patients with advanced kidney cancer.
|
11691814 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CA IX is a tumour-associated carbonic anhydrase with proposed roles in pH modulation and intercellular communication.
|
12115877 |
2002 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In patients with RCC, VHL mutations and significant CA IX expression were seen in established tumor cell lines but not in primary tissue cultures from normal counterparts.
|
12384800 |
2002 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of G250 revealed an inverse correlation to tumor grade.
|
11880110 |
2002 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the present study, we further studied mechanisms of transcriptional regulation of the tumor-associated carbonic anhydrase IX (CAIX).
|
12615703 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Using this approach, we performed a preliminary study investigating the relationship between G250 expression and tumor behavior in clear cell RCC.
|
14660102 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Standard immunohistochemical techniques were used to study CA IX expression in 175 resected NSCLC tumors.
|
12560438 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The first inhibition study of the transmembrane, tumor-associated isozyme CA IX with anions is reported here.
|
14692506 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
CAIX is overexpressed in a variety of tumor types and associated with increased metastasis and poor prognosis.
|
15342400 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Patients with CA IX-positive tumors had a significantly lower disease-specific and overall survival than patients with CA IX-negative tumors (P = 0.033 and P = 0.044, respectively).
|
15240538 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.
|
15556624 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Forty-four primary and 16 recurrent oligodendroglial neoplasms with 1p aberrations (deletion or imbalance) were investigated immunohistochemically for expression of hypoxia-inducible factor 1alpha and carbonic anhydrase-9.
|
15475445 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor tissues were associated with a borderline increase of CA IX staining signal and slight but significant decrease of CA XII immunoreactivity, whereas no association was found for pVHL.
|
15849821 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We correlated array mRNA fold changes with carbonic anhydrase 9 (CA IX) staining of tumours as a surrogate marker of hypoxia.
|
16052224 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In our study, we assessed the expression of DEC1 in 1p aberrant oligodendroglial neoplasms and its association with necrosis and expression of hypoxia-inducible factor 1alpha (HIF-1alpha), carbonic anhydrase-9 (CA9), and vascular endothelial growth factor-mRNA (VEGF).
|
16136500 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Twenty-one of 27 (78%) responding patients had high CAIX expressing tumors compared with 20 of 39 (51%) nonresponders (odds ratio, 3.3; P = 0.04).
|
15897568 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of CA9 gene in tumor cells is principally regulated by the high cell density and the hypoxia-related VHL-HIF pathway.
|
15754010 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The findings suggest that although CA IX-deficiency is not a tumor-promoting factor per se, it induces glandular atrophy in the body mucosa, a lesion which is considered to be a preneoplastic alteration in the stomach.
|
16245156 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of carbonic anhydrase IX in astrocytic tumors predicts poor prognosis.
|
16428489 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Carbonic anhydrase-IX (CA IX) staining of tumor sections was done in the majority of patients (n = 16), as was gene expression profiling (n = 12) using cDNA microarrays.
|
16533775 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The simultaneous overexpression of CA9 and LDH-5 was related to very low pH levels in the veins draining the tumor, suggesting an intense acidification of the tumor microenvironment in such cases.
|
16984378 |
2006 |